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        Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams

        While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring ...

        Research

        Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

        Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target ...

        Research

        Qualitative Evaluation of a Complex Intervention to Improve Rheumatic Heart Disease Secondary Prophylaxis

        A multifaceted intervention was implemented using quality improvement and chronic care model approaches to improve delivery of penicillin prophylaxis for rheumatic heart disease ...

        Research

        Improving delivery of secondary prophylaxis for rheumatic heart disease in a high-burden setting: Outcome of a stepped-wedge, community, randomized trial

        This strategy did not improve adherence to rheumatic heart disease secondary prophylaxis within the study time frame. ...

        Research

        Histone modifications and their role in epigenetics of atopy and allergic diseases

        This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases ...

        Research

        Rheumatic heart disease in Timor-Leste school students: an echocardiography-based prevalence study

        The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys. Community engagement is essential for ensuring follow-up and the effective delivery of secondary prophylaxis. ...

        Research

        Larger Than Life: Injecting Hope into the Planetary Health Paradigm

        We argue that the success of planetary health solutions is predicated on a more sophisticated understanding of the psychology of prevention and intervention at all scales ...

        Research

        Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion

        We found transient pDC depletion during Pneumovirus infection alone predisposed to severe bronchiolitis in early life and subsequent asthma after reinfection. ...

        Research

        Potential impact of a maternal vaccine for RSV: A mathematical modelling study

        Respiratory syncytial virus is a major cause of respiratory morbidity and one of the main causes of hospitalisation in young children. ...

        Research

        Clinical outcomes for young people with screening-detected and clinically-diagnosed rheumatic heart disease in Fiji

        Young people with screening-detected RHD have worse health outcomes than screen-negative cases in Fiji. ...

        Research

        Planning ahead: the mental health value of natural environments

        Over the past decade, a growing number of studies have linked urban green space and aspects of biodiversity with emotional wellbeing. ...

        Research

        Mannitol challenge testing for asthma in a community cohort of young adults

        We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. ...

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