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        Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors

        Risk factors for the association of Scedosporium in cases of cystic fibrosis (CF) and its clinical implications are poorly understood ...

        Research

        Detection of occult Scedosporium species in respiratory tract specimens in cystic fibrosis (CF) by use of selective media

        Respiratory samples from cystic fibrosis outpatients were cultured on Sabouraud's dextrose agar (SABD) containing antibiotics, Mycosel, and Scedosporium-sel... ...

        Research

        Perinatal risk factors for childhood Type 1 diabetes in Western Australia - a population-based study (1980-2002)

        To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort. ...

        Research

        LIFECYCLE - Early Life Stressors and LifeCycle Health

        Graham Rachel Hall Foong GL RF BAppSci PhD CRFS FANZSRS FThorSoc FERS BSc (hons), PhD, MBiostat Honorary Research Associate Senior Research Fellow 08 6319 1626 Rachel.Foong@telethonkids.org.au Honorary Research Associate Senior Research Fellow ...

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        Modern and traditional diets for Noongar infants

        Breast- & bottle-feeding patterns & the introduction of solid feeds & sugar containing drinks to the dietary intake of a cohort of urban Aboriginal infants ...

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        Breastfeeding and early child development: A prospective cohort study

        Breastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find... ...

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        Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study

        To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development. ...

        Research

        Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

        Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

        Research

        Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

        Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

        Research

        Setting the RECORD straight: Developing a guideline for the reporting of studies conducted using observational routinely collected data

        There has been a dramatic increase in the availability of "routine data" for research purposes, including data from electronic medical records,... ...

        Research

        Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis

        We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation... ...

        Research

        Modelling temperature-driven changes in species associations across freshwater communities

        Due to global climate change–induced shifts in species distributions, estimating changes in community composition through the use of Species Distribution Models has become a key management tool. Being able to determine how species associations change along environmental gradients is likely to be pivotal in exploring the magnitude of future changes in species’ distributions. ...

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