KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

When carbohydrates are ingested prior to moderate-intensity exercise, adding repeated sprints is not significantly detrimental to glycaemic management ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019

Recent studies with synthetic peptides representing allergens and non-allergenic house dust mite proteins now offer new research avenues on HDM induced immune responses ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Respiratory samples from cystic fibrosis outpatients were cultured on Sabouraud's dextrose agar (SABD) containing antibiotics, Mycosel, and Scedosporium-sel... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2007
• May 2007

Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt established the Division of Cell Biology at the Institute's inception in 1990, with his research group's ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome in 765 children (485 diagnosed with autism spectrum disorder (ASD)) within the Australian Autism Biobank. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

We report a term male with congenital acute erythroleukemia who achieved sustained remission with low-dose cytosine arabinoside alone ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

The development of Milk Man followed a best practice approach, including the involvement of a multidisciplinary team and grounding in behavior change theory ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• June 2016

B-cell dysfunction persists in patients with HIV receiving long-term antiretroviral therapy. the causes and consequences of this require further investigation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• April 2016

The aim of this study was to determine whether predictive low glucose management (PLGM) system is effective in preventing insulin-induced hypoglycemia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016