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        373-384 of 678 results for 'CANCER'

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        Effectiveness of public health interventions in reducing the prevalence of Opisthorchis viverrini: a protocol for systematic review and network meta-analysis

        The carcinogenic liver fluke Opisthorchis viverrini is a major public health problem in the Mekong basin region. The liver flukes can induce cholangiocarcinoma, a bile duct cancer that causes a significant burden of mortality and economic loss. Various public health interventions have been conducted to reduce opisthorchiasis but the prevalence of O. viverrini remains high in endemic regions. ...

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        Childhood brain tumours: Associations with parental occupational exposure to solvents

        Paternal exposure to solvents in the year before conception was associated with an increased CBT risk. This increased risk appeared to be mainly attributable... ...

        Research

        Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control study

        The aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT. ...

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        Exposure to pesticides and the risk of childhood brain tumors

        This Australian case-control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were... ...

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        Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumors

        This study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk... ...

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        Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

        KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. ...

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        Down syndrome-associated leukaemias: current evidence and challenges

        Children with Down syndrome (DS) are at increased risk of developing haematological malignancies, in particular acute megakaryoblastic leukaemia and acute lymphoblastic leukaemia. The microenvironment established by abnormal haematopoiesis driven by trisomy 21 is compounded by additional genetic and epigenetic changes that can drive leukaemogenesis in patients with DS. ...

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        Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

        Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

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        Risk factors for symptomatic venous thromboembolism during therapy for childhood acute lymphoblastic leukemia

        We found two known risk factors in a large cohort of children treated for ALL and identified other factors associated with venous thromboembolism ...

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        Stimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndrome

        Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with complex regional pain syndrome. Activating α 1 -adrenoceptors in epidermal cells increases production of the proinflammatory cytokine interleukin-6, a mediator of inflammation. ...

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        Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy

        Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma  relapse and response to immunotherapy.  ...

        Research

        Insights into respiratory disease through bioinformatics

        Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases ...

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