This study investigated the potential of using SARS-CoV-2 viral concentrations in dust as an additional surveillance tool for early detection and monitoring of COVID-19 transmission. Dust samples were collected from 8 public locations in 16 districts of Bangkok, Thailand, from June to August 2021. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

There is now considerable evidence demonstrating that both prenatal and postnatal exposure to particular classes of microbial stimuli can provide beneficial signals during early life immune development, resulting in the protection against future inflammatory disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Anya Deborah Pat Jones Strickland Holt AJ DH PG BSc MSc PhD PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary Research Associate Program Head, Immunobiology and Immunotherapeutic Program Emeritus Honorary Researcher anya.jones@telethonkids.org.au ...

• 1. Telethon Kids Institute
• Projects

We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program
• Pregnancy and Early Life Immunology

The respiratory tract is an attractive target organ for novel diagnostic and therapeutic applications with nano-sized carriers, but their immune effects and... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

The immunological mechanisms that contribute to multiple sclerosis (MS) differ between males and females. Females are 2-3 times more likely to develop MS compared to males, however the reason for this discrepancy is unknown. Once MS is established, there is a more inflammatory yet milder form of disease in females whereas males generally suffer from more severe disease and faster progression, neural degradation, and disability. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM+ B cell subsets in healthy controls. For females with MS or CIS, significantly lower CD32b expression was identified on IgM+ B cell subsets, including naive and IgMhi MZ-like B cells, when compared with control females. Lower CD32b expression on these B cell subsets was associated with detectable anti-Epstein Barr Virus viral capsid antigen IgM antibodies, and higher serum levels of B cell activating factor. To investigate the effects of lower CD32b expression, B cells were polyclonally activated in the presence of IgG immune complexes, with or without a CD32b blocking antibody, and the expression of TNF and IL-10 in B cell subsets was assessed. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Jennifer Peter Kent Richmond J PC RN MBBS MRCP(UK) FRACP Clinical Research Manager Head, Vaccine Trials Group Jennifer.Kent@telethonkids.org.au Clinical Research Manager Head, Vaccine Trials Group Jennifer completed her Diploma of Nursing in 1986 at ...

• 1. Telethon Kids Institute
• Projects