Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Video otoscopy plays an important role in improving access to ear health services. This study investigated the clinician-rated quality of video otoscopy recordings and still images, and compared their suitability for asynchronous diagnosis of middle-ear disease. Two hundred and eighty video otoscopy image-recording pairs were collected from 150 children (aged six months to 15 years) by an ear, nose, and throat (ENT) specialist, audiologists, and trained research assistants, and independently rated by an audiologist and ENT surgeon. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Almost half of stillbirths could be potentially identified antenatally based on a combination of factors ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

A significant reduction in severe influenza was observed in Australian children, possibly contributed to by improved vaccine coverage and high vaccine effectiveness ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

The majority of Australian Aboriginal and Torres Strait Islander (hereafter referred to as “Aboriginal”) people live in urban centres. Otitis media (OM) occurs at a younger age, prevalence is higher and hearing loss and other serious complications are more common in Aboriginal than non-Aboriginal children. Despite this, data on the burden of OM and hearing loss in urban Aboriginal children are limited. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Here, we explore the history of planetary health and describe its relevance to contemporary healthcare ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Infant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Evidence for the existence of additional regulatory mechanisms of the expression of neurodegenerative disease-causing genes by antisense long noncoding RNAs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Respiratory syncytial virus is a major cause of respiratory morbidity and one of the main causes of hospitalisation in young children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017