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        Investigating Mitochondrial Transcriptomes and RNA Processing Using Circular RNA Sequencing

        Transcriptomic technologies have revolutionized the study of gene expression and RNA biology. Different RNA sequencing methods enable the analyses of diverse species of transcripts, including their abundance, processing, stability, and other specific features. Mitochondrial transcriptomics has benefited from these technologies that have revealed the surprising complexity of its RNAs. Here we describe a method based upon cyclization of mitochondrial RNAs and next generation sequencing to analyze the steady-state levels and sizes of mitochondrial RNAs, their degradation products, as well as their processing intermediates by capturing both 5' and 3' ends of transcripts. ...

        Research

        We won't find what we don't look for: Identifying barriers and enablers of chronic wet cough in Aboriginal children

        Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities ...

        Research

        CF derived scoring systems do not fully describe the range of structural changes seen on CT scans in PCD

        Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients ...

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        Minimal residual disease and outcome characteristics in infant KMT2A-germline acute lymphoblastic leukaemia treated on the Interfant-06 protocol

        The outcome of infants with KMT2A-germline acute lymphoblastic leukaemia (ALL) is superior to that of infants with KMT2A-rearranged ALL but has been inferior to non-infant ALL patients. Here, we describe the outcome and prognostic factors for 167 infants with KMT2A-germline ALL enrolled in the Interfant-06 study. ...

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        Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life

        Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. ...

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        Characterization of the transient deficiency of pkc isozyme levels in immature cord blood t cells and its connection to anti‐allergic cytokine profiles of the matured cells

        Cord blood T cells (CBTC) from a proportion of newborns express low/deficient levels of some protein kinase C (PKC) isozymes, with low levels of PKCζ correlating with increased risk of developing allergy and associated decrease in interferon‐gamma (IFN‐γ) producing T cells. ...

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        Earth dreams: Reimagining ARPA for health of people, places and planet

        Bold new approaches are urgently needed to overcome global health challenges. The proposed Advanced Research Projects Agency for Health (ARPA-H) is intended to provide rapid health breakthroughs. ...

        Research

        Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab

        We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). ...

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        The maturation of immune functions in pregnancy and early childhood

        This book chapter explains the maturation of immune functions during pregnancy & in early childhood, and addresses the importance of early environmental... ...

        Research

        Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation

        This study investigates the different patterns of relapse in patients with central nervous system mixed malignant germ cell tumors - treated with chemotherapy. ...

        Research

        Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: A double-blind, parallel controlled trial

        A double-blind, placebo-controlled clinical trial was conducted investigating the use of low-dose oral interferon alpha for preventing acute viral... ...

        Research

        Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity

        Epidermal growth factor receptor (EGFR) is over-expressed in many brain tumors. This paper examines mutations the EGFR that make the cell it is produced in... ...

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