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        Subjective memory complaints predict baseline but not future cognitive function over three years: Results from the Western Australia Memory Study

        Subjective memory complaints individuals present distinctive features of memory complaints as compared to non-memory complainers ...

        Research

        Mandatory vaccination and no fault vaccine injury compensation schemes: An identification of country-level policies

        Countries that mandate childhood vaccination without providing no fault compensation schemes could be seen as abrogating the social contract ...

        Research

        Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome

        Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further ...

        Research

        Impact of social disadvantage on cerebral palsy severity

        In Australia, socio-economic disadvantage at birth impacts adversely on cerebral palsy severity at age 5 years ...

        Research

        Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection

        Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for development of better long-acting penicillin preparations to prevent RHD. ...

        Research

        A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility

        This study highlights an unpredicted potential risk factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk ...

        Research

        Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue

        Non-burning (low-dose) UVR suppresses the BAT 'whitening', steatotic and pro-diabetic effects of consuming a high-fat diet through skin release of nitric oxide ...

        Research

        Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

        Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of Polycomb Repressor Complex 2 (PRC2) target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. ...

        Research

        Spatial patterns of tuberculosis and HIV coinfection in Ethiopia

        Our study provides evidence for geographic clustering of tuberculosis/human immunodeficiency virus co-infection in Ethiopia ...

        Research

        Genetic Manipulation of Group A Streptococcus-Gene Deletion by Allelic Replacement

        An optimized, rapid method for creating markerless isogenic mutations that combines Gibson assembly cloning with a new temperature-sensitive plasmid, pLZts ...

        Research

        Towards the development of an integrative, evidence-based suite of indicators for the prediction of outcome following mild traumatic brain injury

        Performance on neuropsychological measures may be useful for predicting persisting post-concussion symptoms ...

        Research

        Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma model

        We established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model ...

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