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        Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

        The aim of this study was to assess if MMP activation positively correlates with neutrophil elastase activity, disease severity and bronchiectasis in young... ...

        Research

        Gut microbiome and innate immune response patterns in IgE-associated eczema

        Gut microbiome patterns have been associated with predisposition to eczema potentially through modulation of innate immune signalling. ...

        Research

        Maternal fish oil supplementation in pregnancy: a 12 year follow-up of a randomised controlled trial.

        We aimed to investigate the long-term effects (12 years) of fish oil supplementation in pregnancy on neurodevelopment, including cognition, language and fine... ...

        Research

        Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis

        We hypothesized that the presence of these markers of cystic fibrosis lung disease in the first 2 years of life would be associated with reduced lung... ...

        Research

        Improving delivery of secondary prophylaxis for rheumatic heart disease in remote Indigenous communities

        This trial aims to improve uptake of secondary prophylaxis among Aboriginal people with ARF/RHD to reduce progression or worsening of RHD. ...

        Research

        Polygenic risk of ischemic stroke is associated with cognitive ability

        Findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability ...

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        Relationships between Psychosocial Resilience and Physical Health Status of Western Australian Urban Aboriginal Youth

        The aim of this study was to investigate the extent to which factors previously documented as buffering the impact of high-risk family environments on... ...

        Research

        The relationship between maternal psychiatric disorder, autism spectrum disorder and intellectual disability in the child: a composite picture

        Research conducted by this laboratory has previously published four papers examining the relationship between maternal psychiatric disorders and having a... ...

        Research

        Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil

        Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. ...

        Research

        A systematic approach to multiple breath nitrogen washout test quality

        The application of the systematic review improved inter-observer agreement but did not affect reported multiple breath washout outcomes ...

        Research

        Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data

        Here we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their... ...

        Research

        Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

        We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. ...

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