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        Puberty suppression in transgender children and adolescents

        We review the available empirical evidence on the cognitive, physical, and surgical implications of puberty suppression in gender-incongruent children and adolescents ...

        Research

        Immunisation and pregnancy - who, what, when and why?

        Recommending vaccination to pregnant women is important as evidence shows they are more likely to get vaccinated if their healthcare provider advises it ...

        Research

        Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

        HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

        Research

        Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015

        Globally, life expectancy from birth increased from 61·7 years in 1980 to 71·8 years in 2015 ...

        Research

        Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015

        Total global disability-adjusted life-years remained largely unchanged from 1990 to 2015 ...

        Research

        Efficacy of a trivalent influenza vaccine against seasonal strains and against 2009 pandemic H1N1: A randomized, placebo-controlled trial

        This study assessed the efficacy of seasonal IIV3s against influenza due to 2008 and 2009 seasonal influenza strains and against the 2009 pandemic H1N1 strain ...

        Research

        Impaired airway epithelial cell responses from children with asthma to rhinoviral infection

        Human rhinovirus infection delays repair and inhibits apoptotic processes in epithelial cells from non-asthmatic and asthmatic children ...

        Research

        Informing rubella vaccination strategies in East Java, Indonesia through transmission modelling

        A single dose of rubella vaccine will take longer to reduce the burden of rubella and will be less robust to lower vaccine coverage ...

        Research

        iming of Introduction of Solids and Early-Onset Allergic Disease

        Strategies to prevent early-life food allergen sensitisation prior to commencement of solid foods are needed and should be the focus of future research ...

        Research

        Asbestos exposure and histological subtype of malignant mesothelioma

        Pathological malignant mesothelioma subtype is associated with the type of asbestos or the attributes of asbestos exposure ...

        Research

        Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

        In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. ...

        Research

        Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathways

        Our results provide a possible functional link between Toxoplasma gondii infection and congenital/early life and adult neurological clinical signs ...

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