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        Parents’ attitudes towards the No Jab No Play legislation in Western Australia: a mixed methods study

        Mandates provide a relatively cost-effective strategy to increase vaccinate rates. Since 2014, five Australian states have implemented No Jab No Play (NJPlay) policies that require children to be fully immunised to attend early childhood education and childcare services. In Western Australia, where this study was conducted, NJNPlay legislation was enacted in 2019.  ...

        Research

        Development of best practice guidelines for clinical and community service providers to prevent suicide in LGBTQA+ young people: A Delphi expert consensus study

        The aim of this study was to develop best practice guidelines for preventing suicide and reducing suicidal thoughts and behaviours in LGBTQA+ young people (lesbian, gay, bisexual, trans, queer/questioning, asexual, and those of other diverse sexualities and genders) within clinical and community service settings in Australia. ...

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        CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural induction

        An estimated 3.5%-5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic delays of 5-30 years. Next-generation sequencing has improved clinical diagnostic rates to 33%-48%. In a majority of cases, novel variants potentially causing the disease are discovered.  ...

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        Antibiotics or watchful waiting for acute otitis media in urban Aboriginal and Torres Strait Islander children?

        Chris Valerie Brennan-Jones Swift C VS PhD Head, Ear Health Aboriginal Co-Director, Djaalinj Waakinj Centre for Ear and Hearing Health; Aboriginal Cultural Guidance Advisor chris.brennan-jones@telethonkids.org.au Valerie.Swift@telethonkids.org.au ...

        Research

        Early diet quality in a longitudinal study of Australian children: Associations with nutrition and body mass index later in childhood and adolescence

        The aims of this study were to determine whether early childhood dietary quality was associated with infant and adolescent nutrition, and body mass index. ...

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        Changes in thymic regulatory T-cell maturation from birth to puberty: Differences in atopic children

        We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young... ...

        Research

        Exploring indoor and outdoor dust as a potential tool for detection and monitoring of COVID-19 transmission

        This study investigated the potential of using SARS-CoV-2 viral concentrations in dust as an additional surveillance tool for early detection and monitoring of COVID-19 transmission. Dust samples were collected from 8 public locations in 16 districts of Bangkok, Thailand, from June to August 2021. ...

        Research

        Prevalence of Eating Disorder Symptoms in Transgender and Gender Diverse Adolescents Presenting for Gender-Affirming Care

        To describe the prevalence of eating disorder symptoms among adolescents seeking gender-affirming care. ...

        Research

        Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling study

        The Philippines reports a high prevalence of soil-transmitted helminth (STH) infections despite the implementation of nationwide mass drug administration since 2006. The spatial variation of STH infections in the Philippines was last described using the 2005-2007 national STH and schistosomiasis survey. This study aimed to identify sociodemographic and environmental factors that drive STH transmission and predict high-risk areas in the Philippines. ...

        Research

        Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

        Neisseria meningitidis is commensal of the human pharynx and occasionally invades the host, causing the life-threatening illness invasive meningococcal disease. The meningococcus is a highly diverse and adaptable organism thanks to natural competence, a propensity for recombination, and a highly repetitive genome. ...

        Research

        Airway management in neonates and infants: European Society of Anaesthesiology and Intensive Care and British Journal of Anaesthesia joint guidelines

        Airway management is required during general anaesthesia and is essential for life-threatening conditions such as cardiopulmonary resuscitation. Evidence from recent trials indicates a high incidence of critical events during airway management, especially in neonates or infants. It is important to define the optimal techniques and strategies for airway management in these groups. ...

        Research

        A Maximum Entropy Model of the Distribution of Dengue Serotype in Mexico

        Pathogen strain diversity is an important driver of the trajectory of epidemics. The role of bioclimatic factors on the spatial distribution of dengue virus serotypes has, however, not been previously studied. Hence, we developed municipality-scale environmental suitability maps for the four dengue virus serotypes using maximum entropy modeling. ...

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