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        Association between interpregnancy interval and adverse birth outcomes in women with a previous stillbirth: an international cohort study

        Conception within 12 months of a stillbirth was common and was not associated with increased risk of adverse outcomes in the subsequent pregnancy ...

        Research

        Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: Systematic review and meta-analysis

        Nonrecurrent risk of stillbirth, Preterm birth, and small for gestational age after exposure to one or more of these complications in a previous pregnancy ...

        Research

        The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia, 2013-2015

        Seasonal influenza is an important cause of acute neurological disease in Australian children. ...

        Research

        Twenty-Five Year Survival of Children with Intellectual Disability in Western Australia

        To investigate survival up to early adulthood for children with intellectual disability and compare their risk of mortality with that of children without intellectual disability. ...

        Research

        Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births

        The positive association between caesarean section (CS) and autism spectrum disorder (ASD) may be attributed to preterm delivery. ...

        Research

        Viral etiology and the impact of codetection in young children presenting with influenza-like illness

        Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious. ...

        Research

        RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

        T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

        Research

        Outcomes and endpoints reported in studies of pulmonary exacerbations in people with cystic fibrosis: A systematic review

        There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations in people with cystic fibrosis (CF). Outcomes used for evaluation should be meaningful; that is, they should capture how people feel, function or survive and be acknowledged as important to people with CF, or should be reliable surrogates of those outcomes. We aimed to summarise the outcomes and corresponding endpoints which have been reported in studies of pulmonary exacerbations, and to identify those which are most likely to be meaningful. ...

        Research

        Excess respiratory mortality and hospitalizations associated with influenza in Australia, 2007-2015

        Influenza is the most common vaccine-preventable disease in Australia, causing significant morbidity and mortality. We assessed the burden of influenza across all ages in terms of influenza-associated mortality and hospitalizations using national mortality, hospital-discharge and influenza surveillance data. ...

        Research

        Parent and therapist perspectives on "uptime" activities and participation in Rett syndrome

        People with a disability may spend more time sitting and lying (“downtime”) and less time standing and walking (“uptime”). Caregivers and therapists supporting individuals with Rett syndrome were surveyed, aiming to gather insights on how to support participation in “uptime” activities. ...

        Research

        Clinical description and outcomes of Australian children with invasive group a streptococcal disease

        Invasive group A streptococcal infection in Australian children is frequently severe and has a high long-term morbidity burden ...

        Research

        The relationship between maternal psychiatric disorder, autism spectrum disorder and intellectual disability in the child: a composite picture

        Research conducted by this laboratory has previously published four papers examining the relationship between maternal psychiatric disorders and having a... ...

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