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        409-420 of 1480 results for 'Infectious disease'

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        A national prospective surveillance study of acute rheumatic fever in Australian children

        Acute rheumatic fever (ARF) is an important cause of heart disease in Indigenous people of northern and central Australia. ...

        Research

        Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie-Boulder

        To investigate antimicrobial susceptibility of Moraxella catarrhalis isolated from a cohort of children being followed in a study of the natural history of OM ...

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        "Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New Zealand

        Four-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG. ...

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        Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

        Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism.  ...

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        The non-specific effects of maternal immunization on birth outcomes: The evidence, mechanisms, and the implications

        Preterm birth (PTB) and stillbirth remain two of the most important causes of death, morbidity, and disability in childhood. Despite efforts to reduce PTB and stillbirth worldwide, rates of these adverse outcomes remain persistently elevated, independent of income setting. There is an urgent need for more effective interventions to reduce associated neonatal and early childhood morbidity and mortality. ...

        Research

        Randomised clinical trial using Coronary Artery Calcium Scoring in Australian Women with Novel Cardiovascular Risk Factors (CAC-WOMEN Trial): Study protocol

        Cardiovascular disease (CVD) is the leading cause of death in women around the world. Aboriginal and Torres Strait Islander women (Australian Indigenous women) have a high burden of CVD, occurring on average 10-20 years earlier than non-Indigenous women. ...

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        Pediatric Staphylococcus aureus Bacteremia: Clinical Spectrum and Predictors of Poor Outcome

        Staphylococcus aureus is a common cause of bacteremia, yet the epidemiology and predictors of poor outcome remain inadequately defined in childhood. ISAIAH (Invasive Staphylococcus aureus Infections and Hospitalizations in children) is a prospective, cross-sectional study of S. aureus bacteremia in children hospitalized in Australia and New Zealand over 24 months. ...

        Research

        Impacts of armed conflicts on tuberculosis burden and treatment outcomes: a systematic review

        This systematic review aimed to summarise existing literature on the impacts of armed conflicts on tuberculosis burden and treatment outcomes. ...

        Research

        Sero-epidemiology of SARS-CoV-2V-2 in Western Australia

        Christopher Asha Blyth Bowen CC AC MBBS (Hons) DCH FRACP FRCPA PhD BA MBBS DCH FRACP PhD GAICD Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases Epidemiology, Wesfarmers Centre of Vaccines and Infectious ...

        Research

        Can linked emergency department data help assess the out-of-hospital burden of acute lower respiratory infections

        There is a lack of data on the out-of-hospital burden of acute lower respiratory infections (ALRI) in developed countries. ...

        Research

        10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose

        18 months of age infants receiving 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine will have higher antibody levels ...

        Research

        Histiologic chorioamnionitis is associated with reduced incidence of late-onset sepsis in very preterm infants

        Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis... ...

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