Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012

Natural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellular therapies using cytokine-activated NK cells have emerged as promising treatments for patients with advanced leukaemia. However, not all patients respond to current NK cell therapies, and thus improvements in efficacy are required. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Optic pathway gliomas (OPGs) are associated with significant risk of visual and endocrine morbidity, but data on long-term outcomes in symptomatic patients is sparse. This study reviews the clinical course, disease progression, survival outcomes and long-term sequelae in pediatric patients with symptomatic OPGs in our institution over three decades. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Tissue-resident memory T (TRM) cells have emerged as key players in the immune control of melanoma. These specialized cells are identified by expression of tissue retention markers such as CD69, CD103 and CD49a with downregulation of egress molecules such as Sphingosine-1-Phosphate Receptor-1 (S1PR1) and the lymphoid homing receptor, CD62L. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

These findings may help to explain the decrease in external GW diagnoses seen in England. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• November 2013

Clustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• March 2013

Here we describe a method by which serial biopsy can be used to validate response to dacomitinib treatment in vivo using a mouse glioblastoma model ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

These findings provide a compelling argument for efforts to reduce exposure of the brainstem in the treatment of medulloblastoma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including diseases... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Natural killer (NK) cells play a significant and vital role in the first line of defense against infection through their ability to target cells without prior sensitization. They also contribute significantly to the activation and recruitment of both innate and adaptive immune cells through the production of a range of cytokines and chemokines. In the context of cytomegalovirus (CMV) infection, NK cells and CMV have co-evolved side by side to employ several mechanisms to evade one another. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020