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        409-420 of 1335 results for 'curtin'

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        RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

        T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

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        Murine bone-derived mesenchymal stem cells undergo molecular changes after a single passage in culture

        The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown to alter primary MSC properties. ...

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        Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Graham Stephen Hall Stick GL SM BAppSci PhD CRFS FANZSRS FThorSoc FERS MB BChir PhD MRCP FRACP Honorary Research Associate Head, P4 Respiratory Health for Kids Honorary Research Associate Head, P4 Respiratory Health for Kids Professor Graham Hall is ...

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        SPARX-T: An online game to prevent depression in trans young people

        Yael Penelope Helen Holly Perry Strauss Morgan Moss YP PS HM HM BPsych (Hons) MPsych (Clin) PhD BA, MPH, PhD BA (Hons), Doctor of Psychology BEd Program Head, Mental Health & Youth; Head, Youth Mental Health Research Fellow in Youth Suicide ...

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        Antibiotics or watchful waiting for acute otitis media in urban Aboriginal and Torres Strait Islander children?

        Chris Valerie Brennan-Jones Swift C VS PhD Head, Ear Health Aboriginal Co-Director, Djaalinj Waakinj Centre for Ear and Hearing Health; Aboriginal Cultural Guidance Advisor chris.brennan-jones@telethonkids.org.au Valerie.Swift@telethonkids.org.au ...

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        Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

        High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of chemotherapy. However, enhancements in drug efficacy have been limited because of a lack of selectivity of the liposomal formulations for the cancer cells. ...

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        The Use of Serious Gaming to Improve Sensorimotor Function and Motivation in People with Cerebral Palsy: A Systematic Review

        The aim of this systematic review was to review the evidence for serious gaming interventions in improving sensorimotor function in children and adults with cerebral palsy (CP). Seven databases were searched with terms related to serious gaming and CP. ...

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        Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants

        Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

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        Implementation of an Early Communication Intervention for Young Children with Cerebral Palsy Using Single-Subject Research Design

        The implementation of an intervention protocol aimed at increasing vocal complexity in three pre-linguistic children with cerebral palsy (two males, starting age 15 months, and one female, starting age 16 months) was evaluated utilising a repeated ABA case series design. The study progressed until the children were 36 months of age. Weekly probes with trained and untrained items were administered across each of three intervention blocks. ...

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        Technical standards for respiratory oscillometry

        The aim of the task force was to provide technical recommendations regarding oscillometry measurement ...

        Research

        Bullying and psychosocial adjustment among children with and without asthma

        Children with asthma face serious mental health risk, but the pathways remain unclear. This study aimed to examine bullying victimisation and perpetration in children with asthma and a comparison sample without a chronic health condition, and the role of bullying in moderating psychosocial adjustment outcomes for those with asthma. A sample of children with and without asthma, and their parents, were recruited from hospital clinics. ...

        Research

        The safety and feasibility of the inhaled mannitol challenge test in young children

        Mannitol challenge tests are used clinically to diagnose asthma and, in particular, exercise-induced broncoconstriction (EIB) in adults and children above 6... ...

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