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        Educational Outcomes of Children in Contact with the Child Protection System: A Longitudinal Population Study

        Melissa Fiona Helen O'Donnell Stanley Leonard M FJ HM BPsych (Hons), MPsych, GradDip Ed, PhD FAA FASSA MSc MD FFPHM FAFPHM FRACP FRANZCOG HonDSc HonDUniv HonFRACGP HonMD HonFRCPCH HonLLB (honoris causa) MBChB MPH Honorary Research Associate Patron ...

        Research

        Vitamin D and immunity

        The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,... ...

        Research

        IgG3 + B cells are associated with the development of multiple sclerosis

        We have identified previously uncharacterised subsets of IgG3 + B cells and shown them to correlate with autoimmune attacks on the central nervous system ...

        Research

        Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

        These results indicate that T regulatory (Treg) and follicular T regulatory (Tfr) impairment is an early feature in MS. ...

        Research

        Immune cell trafficking from the brain maintains CNS immune tolerance

        Evaluation of fluorescently labeled leukocyte migration in mice revealed that DCs travel via the RMS from the CNS to the cervical LNs (CxLNs), where they... ...

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        Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+

        Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located... ...

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        Setting the RECORD straight: Developing a guideline for the reporting of studies conducted using observational routinely collected data

        There has been a dramatic increase in the availability of "routine data" for research purposes, including data from electronic medical records,... ...

        Research

        Breastfeeding and early child development: A prospective cohort study

        Breastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find... ...

        Research

        Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis

        We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation... ...

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        Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

        Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

        Research

        Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

        Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

        Research

        Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study

        To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development. ...

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