Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012

The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown to alter primary MSC properties. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers has the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three independent IPF cohorts, the Australian IPF Registry (AIPFR), Trent Lung Fibrosis (TLF) and Prospective Observation of Fibrosis in the Lung Clinical Endpoints (PROFILE). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Invasive fungal disease (IFD) is a common and important complication in children with acute myeloid leukaemia (AML). We describe the epidemiology of IFD in a large multicentre cohort of children with AML. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The way the immune system operates differs between males and females. This is due to both differential expression of immune-related genes from the sex chromosomes as well as the immune modulatory properties of sex hormones. Together, these effects contribute to a skewed prevalence of disease and disease course between males and females, including allergic-, infectious-, autoimmune-, and cancerous disease. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Due to the extensive past use of asbestos in Australia, known exposure is common and causes anxiety, especially with the increased risk of thoracic malignancies ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

We compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

We derived a simple ordinary differential equation-based model using Michaelis–Menten Kinetics to process the microarray data ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

This study aimed to identify sources whereby people in Western Australia (WA) may be unknowingly exposed to asbestos or to other exposures which may cause MM. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017