These findings provide a compelling argument for efforts to reduce exposure of the brainstem in the treatment of medulloblastoma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Here we describe a method by which serial biopsy can be used to validate response to dacomitinib treatment in vivo using a mouse glioblastoma model ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including diseases... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown to alter primary MSC properties. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

The way the immune system operates differs between males and females. This is due to both differential expression of immune-related genes from the sex chromosomes as well as the immune modulatory properties of sex hormones. Together, these effects contribute to a skewed prevalence of disease and disease course between males and females, including allergic-, infectious-, autoimmune-, and cancerous disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers has the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three independent IPF cohorts, the Australian IPF Registry (AIPFR), Trent Lung Fibrosis (TLF) and Prospective Observation of Fibrosis in the Lung Clinical Endpoints (PROFILE). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Invasive fungal disease (IFD) is a common and important complication in children with acute myeloid leukaemia (AML). We describe the epidemiology of IFD in a large multicentre cohort of children with AML. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Due to the extensive past use of asbestos in Australia, known exposure is common and causes anxiety, especially with the increased risk of thoracic malignancies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

We compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019