Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORIGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

As we discuss, equal weekly visits to major fast-food outlets by the affluent and deprived do not translate into biological equivalency. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Gut microbiome patterns have been associated with predisposition to eczema potentially through modulation of innate immune signalling. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

A hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• May 2012

The diagnosis of food allergy (FA) can be challenging because approximately half of food-sensitized patients are asymptomatic. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

How females with Rett syndrome communicate in everyday life and the barriers and facilitators to successful communication ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

This article discusses the relationships between gut colonization & inflammatory noncommunicable diseases, in regards to their treatment and prevention. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

The COVID-19 pandemic has posed significant challenges for healthcare workers worldwide, potentially affecting their sense of coherence (SOC) and overall well-being. This study aimed to identify factors associated with different levels of SOC among healthcare workers, exploring demographic characteristics, work-related factors, changes in relationships and social habits, and the overall well-being. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

We examined the relationship between the onset and pattern of childhood mental health disorders and subsequent current smoking status at age 17 years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• May 2012

In the ongoing debate on optimum methods for identification of Indigenous people within linked administrative data, few studies have examined the impacts of method on population counts and outcomes in family-based linkage studies of Aboriginal children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020