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        Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions

        Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk. ...

        Research

        Sun-immune connection

        Exposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system ...

        Research

        HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

        HLA-A*32:01 is strongly associated with vancomycin-induced DRESS in a population of predominantly European ancestry ...

        Research

        Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case–control study

        The aim of this study was to describe the characteristics of patients with multidrug-resistant tuberculosis and to investigate risk factors ...

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        Long-term economic outcomes for interventions in early childhood: protocol for a systematic review

        Investment in early childhood produces positive returns: for the child, the family and the community. ...

        Research

        Can the CHA2 DS2 -VA schema be used to decide on anticoagulant therapy in Aboriginal and other Australians with non-valvular atrial fibrillation?

        The Australasian guidelines recommend use of the CHA2 DS2 -VA schema to stratify ischaemic stroke risk in patients with non-valvular atrial fibrillation (N-VAF) and determine risk thresholds for recommending oral anticoagulant (OAC) therapy. However, the CHA2 DS2 -VA score has not been validated in a representative Australian population cohort with N-VAF, including in Aboriginal people who are known to have a higher age-adjusted stroke risk than other Australians. ...

        Research

        Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

        Type 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations ...

        Research

        Feasibility Testing and Refinement of a Supportive Educational Intervention for Carers of Patients with High-Grade Glioma — a Pilot Study

        The aim of this pilot study was to test the feasibility and acceptability of a family carer intervention for carers of patients with high-grade glioma ...

        Research

        Aboriginal parent support: A partnership approach

        Our aim was to identify program elements, exploring participants’ perceptions of the program's suitability, feasibility, acceptability and effectiveness. ...

        Research

        Latent profiles of early developmental vulnerabilities in a New South Wales child population at age 5 years

        Patterns of early childhood developmental vulnerabilities may provide useful indicators for particular mental disorder outcomes in later life ...

        Research

        Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volume

        The aim of this study was to determine whether assessment of early CT scan-detected bronchiectasis in young children with cystic fibrosis (CF) depends on... ...

        Research

        Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103− and XCR1+CD103+ dendritic cells

        This report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance ...

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