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        Improving delivery of secondary prophylaxis for rheumatic heart disease in a high-burden setting: Outcome of a stepped-wedge, community, randomized trial

        This strategy did not improve adherence to rheumatic heart disease secondary prophylaxis within the study time frame. ...

        Research

        State transitions across the Strep A disease spectrum: scoping review and evidence gaps

        The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions. ...

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        Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis

        Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and adults. Varicella symptoms are usually self-limiting; however, different complications with widespread and systemic manifestations can occur. This systematic literature review aims to explore and quantify varicella-associated complication rates. ...

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        Associations between sun exposure, skin pH, and epidermal permeability in pregnancy: A longitudinal observational study

        Little is known about how sun exposure may affect the maternal skin barrier during pregnancy when many hormonal and physiological changes occur. In this longitudinal observational study, 50 pregnant women were recruited at 18-24 weeks' gestation, 25 in summer-autumn, and 25 in winter-spring. At three time points in pregnancy at 18-24, 28-30, and 36-38 weeks' gestation, participants completed a validated sun exposure questionnaire and had skin permeability and surface pH measured on the volar forearm. ...

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        A health inequality analysis of childhood asthma prevalence in urban Australia

        Long-standing health inequalities in Australian society that were exposed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic were described as "fault lines" in a recent call to action by a consortium of philanthropic organizations. With asthma a major contributor to childhood disease burden, studies of its spatial epidemiology can provide valuable insights into the emergence of health inequalities early in life. ...

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        PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

        Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. ...

        Research

        Financial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study

        To assess the level of financial toxicity of informal caregivers of colorectal cancer patients and explore the related key influencing factors. ...

        Research

        Clarithromycin therapy for patients with Cystic Fibrosis: A randomized controlled trial

        The clinically significant actions of oral azithromycin in modifying progressive cystic fibrosis (CF) lung disease have been well documented. ...

        Research

        A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa

        Lymphocyte recruitment to peripheral tissues is fundamental for immune surveillance and homeostasis, but the chemokines and chemokine receptors responsible... ...

        Research

        Multiple prenatal ultrasound scans and ocular development: 20-year follow-up of a randomized controlled trial

        Through comprehensive ophthalmic examination of adult offspring we sought to determine the impact of multiple prenatal ultrasound scans on ocular development. ...

        Research

        Prophylactic use of sublingual allergen immunotherapy in high-risk children: A pilot study

        These findings suggest that this modified version of SLIT should be considered for retesting of mucosal-based immunotherapy for atopic asthma prevention. ...

        Research

        Alcohol-use disorders during and within one year of pregnancy: A population-based cohort study 1985-2006

        Given the severe risks to the fetus from heavy prenatal alcohol exposure, assessment and recording of alcohol use should be routinely undertaken in maternity... ...

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