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        Tissue-resident memory T cells in the era of (Neo) adjuvant melanoma management

        Tissue-resident memory T (TRM) cells have emerged as key players in the immune control of melanoma. These specialized cells are identified by expression of tissue retention markers such as CD69, CD103 and CD49a with downregulation of egress molecules such as Sphingosine-1-Phosphate Receptor-1 (S1PR1) and the lymphoid homing receptor, CD62L. ...

        Research

        Efficacy of the HPV-16/18 AS04-adjuvanted vaccine against low-risk HPV types (PATRICIA Randomized Trial): An unexpected observation

        These findings may help to explain the decrease in external GW diagnoses seen in England. ...

        Research

        Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia

        Clustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done. ...

        Research

        Mitochondrial Gene Therapy

        Aleksandra Filipovska AF BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for Synthetic Biology; Adjunct Research Professor, Monash University Louis Landau Chair in Child Health ...

        Research

        Genetic and environmental factors in the aetiology of hypospadias

        The increasing use of assisted reproductive techniques and hormonal manipulation during pregnancy may have been associated with an apparent rise in the... ...

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        Post hoc analysis of the PATRICIA randomized trial of the efficacy of human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine

        The efficacy of the human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine against cervical infections with HPV... ...

        Research

        Predicting survival in malignant mesothelioma

        Malignant mesothelioma (MM) of the pleura or peritoneum is a universally fatal disease attracting an increasing range of medical interventions and escalating... ...

        Research

        Exposure to diagnostic radiological procedures and the risk of childhood acute lymphoblastic leukemia

        Diagnostic irradiation of the mother during pregnancy increases the risk of childhood acute lymphoblastic leukemia ...

        Research

        Engineering new tools to improve energy metabolism

        Aleksandra Filipovska AF BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for Synthetic Biology; Adjunct Research Professor, Monash University Louis Landau Chair in Child Health ...

        Research

        Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma

        This study examines survival differences between patients with epithelioid MM diagnosed by cytology only and other subtypes diagnosed by histology. ...

        Research

        Blinatumomab as bridging therapy in paediatric B-cell acute lymphoblastic leukaemia complicated by invasive fungal disease

        Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines recommend withholding chemotherapy to facilitate immune recovery in this setting, yet prolonged delays in leukaemia therapy increase risk of relapse. ...

        Research

        Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage

        This study helps us understand how cancer cells are regulated by key genes and their corresponding networks to alter their fate in response to specific... ...

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