ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in ABCA3 can result in severe respiratory disease in infants and children. To study ABCA-3 deficiency in vitro, primary AT-II cells would be the cell culture of choice although sample accessibility is limited. Our aim was to investigate the suitability of primary nasal epithelial cells, as a surrogate culture model for AT-II cells, to study ABCA-3 deficiency. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Melissa Gail Jenny Andrew Licari Alvares Downs Whitehouse Watch and listen to Andrew ML GA JA AJ PhD PhD BApplSci (physio) MSc PhD PhD Senior Research Fellow Senior Research Fellow Program Head, Development and Disability Angela Wright Bennett ...

• Telethon Kids Institute
• Projects

A prior episode of deliberate self-harm (DSH) is one of the strongest predictors of future completed suicide. Identifying antecedents of DSH may inform strategi ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

This WA data linkage study aims to assess whether maternal mental health problems are associated with worse child development outcomes, children’s safety and... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015

School bullying is a public health concern affecting the physical and mental health of children and young people. While school-based interventions to prevent bullying have been developed internationally, the effectiveness of many interventions has been mixed and modest. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

We suggest that 37 weeks' gestation may not be the optimal cutoff for defining perinatal risk as it applies to behavioural development. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013

Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

24-hour Movement Guidelines for the Early Years promote that achieving all three-movement behaviour (sleep, sedentary behaviour and physical activity) recommendations is important for child health and development. We examined the association between meeting all, none and combinations of the Australian 24-Hour Movement Guidelines for the Early Years and social-emotional development in 1363 preschool (2-5 years) boys (52%) and girls. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

The similarities in risk factors and in the adjusted rates of victimisation-related injury admission in both countries suggest that the VR cluster of ICD-10... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• July 2013

Young people who have been involved in the child protection system are at increased risk for mental health events and diagnoses ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019