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        Dendritic cells and cancer: From biology to therapeutic intervention

        In this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity ...

        Research

        Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

        Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

        Research

        Narrowband UVB phototherapy reduces TNF production by B-cell subsets stimulated via TLR7 from individuals with early multiple sclerosis

        At the end of a 60-day course of narrowband UVB phototherapy, administered to individuals with early multiple sclerosis, there were changes in the relative proportions of circulating B-cell subsets. This study investigated phototherapy-associated changes to cytokine responses of B cells when exposed to a TLR7 ligand. ...

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        Panel 8: Vaccines and immunology

        Review and highlight of the significant advances made towards vaccine development and understanding of the immunology of otitis media ...

        Research

        Germline Elongator mutations in Sonic Hedgehog medulloblastoma

        Genetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers ...

        Research

        Differences in stroke risk and cardiovascular mortality for Aboriginal and other Australian patients with atrial fibrillation

        Stroke risk and cardiovascular mortality are markedly higher for Aboriginal than non-Aboriginal patients with atrial fibrillation, particularly for patients under 60 ...

        Research

        Rheumatic heart disease in pregnancy: Profile of women admitted to a Western Australian tertiary obstetric hospital

        This retrospective study assessed maternal and perinatal outcomes for women with rheumatic heart disease admitted to the largest tertiary obstetric hospital ...

        Research

        Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

        We demonstrate a distinct gut virome profile in infants of mothers with type 1 diabetes, which may influence health outcomes later in life ...

        Research

        Misgendering and experiences of stigma within health care settings for transgender individuals

        Misgendering within the health care system can significantly affect the mental and physical health of transgender individuals ...

        Research

        A spatio-temporal analysis to identify the drivers of malaria transmission in Bhutan

        Hot spots and clusters of both species were isolated in the central southern part of Bhutan bordering India ...

        Research

        Volatiles or TIVA: Which is the standard of care for pediatric airway procedures? A pro-con discussion

        This pro-con discussion examines both volatiles and TIVA, from the perspective of effectiveness, safety, cost, and environmental impact, ...

        Research

        Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studies

        The co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures ...

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