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        Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia

        PEGasparaginase is known to be a critical drug for treating pediatric acute lymphoblastic leukemia (ALL), however, there is insufficient evidence to determine the optimal dose for infants who are less than one year of age at diagnosis. This international study was conducted to identify the pharmacokinetics of PEGasparaginase in infants with newly diagnosed ALL and gather insight into the clearance and dosing of this population. ...

        Research

        Intranasal Insulin Trial II

        Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research Co-head, Diabetes and Obesity Research Head, Chronic & Severe Diseases Research Focus Area; ...

        Research

        Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia

        A higher incidence of pediatric intracranial germ cell tumors (iGCTs) in Asian countries compared with Western countries has been reported. In Malaysia, the literature regarding pediatric iGCTs have been nonexistent. The aim of this study was to review the management, survival, and long-term outcomes of pediatric iGCTs at a single tertiary center in Malaysia. ...

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        What matters for people with brain cancer? Selecting clinical quality indicators for an Australian Brain Cancer Registry

        The goal of a clinical quality registry is to deliver immediate gains in survival and quality of life by delivering timely feedback to practitioners, thereby ensuring every patient receives the best existing treatment. We are developing an Australian Brain Cancer Registry (ABCR) to identify, describe, and measure the impact of the variation and gaps in brain cancer care from the time of diagnosis to the end of life. ...

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        Reduced socs1 expression in lung fibroblasts from patients with ipf is not mediated by promoter methylation or mir155

        The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and function are unknown. Suppressor of cytokine signaling (SOCS)1 and SOCS3 block STAT3, and low SOCS1 levels have been reported in IPF fibroblasts and shown to facilitate collagen production. Fibroblasts and lung tissue from IPF patients and controls were used to examine the mechanisms underlying SOCS1 down-regulation in IPF. ...

        Research

        A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors

        In this. i study the MTD and RP2D, safety, PK, and preliminary activity of single-agent ribociclib were investigated in patients with neuroblastoma. ...

        Research

        The collective impact of rare diseases in Western Australia: An estimate using a population-based cohort

        This cohort study provides new evidence of a disparity between the proportion of the population with rare diseases and their combined health-system costs ...

        Research

        Contemporary survival endpoints: An international diffuse intrinsic pontine glioma registry study

        This study defines PFS and OS, and is the first describe post-progression survival in a large cohort of children with DIPG. ...

        Research

        Barriers to Parent–Child Book Reading in Early Childhood

        Parent–child book reading interventions alone are unlikely to meet needs of children and families for whom the absence of reading is psychosocial risk factor ...

        Research

        Vitamin and mineral supplements: Gut health and probiotics: Probiotics for a healthy microbiome: An evidence-based approach to appropriate product choice

        This review discusses the available evidence base to help provide practical guidance when considering probiotics in practice ...

        Research

        A national guideline for the assessment and diagnosis of autism spectrum disorders in Australia

        The Guideline aims to create greater consistency in diagnostic practices across the country to ensure individuals on the autism spectrum can receive the optimal care ...

        Research

        Testing for Response Shift Bias in Evaluations of School Antibullying Programs

        Researchers conducting program evaluations in other contexts are advised to consider testing for this potential source of bias in their studies ...

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