The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The Rare and Undiagnosed Diseases Diagnostic Service refers to a genomic diagnostic platform operating within the Genetic Services of Western Australia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Daily physical activity is critical during the early years of life for facilitating children's health and development. A large proportion of preschool children do not achieve the recommended 3 h of daily physical activity. Early childhood education and care (ECEC) services are a key setting to intervene to increase physical activity. There is a significant need for ECEC specific physical activity policy, including clearer guidelines on the amount of physical activity children should do during care, and strategies for implementation of these guidelines. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

These data suggest that the link between maternal hypertensive diseases of pregnancy and child behavioral development begins in the first year of life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013

Findings show that indicators of a poor intrauterine environment are associated with an elevated risk of ID, while for ASD, and particularly ASD without ID,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Marked increases in maternal age and primiparous births were observed. A four-fold increase in the rates of pre-existing medical complications over time... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

We suggest that 37 weeks' gestation may not be the optimal cutoff for defining perinatal risk as it applies to behavioural development. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• April 2013

This data set provides a useful reference point for genomic studies on Aboriginal Australians ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• April 2016

Each day of school missed makes a difference, with the effect on learning accumulating over time. From an early age, if children are taught that they need to 'show up' for school and make a commitment, this positive mentality aids academic and career success and brings benefits in adulthood. ...

• 1. Telethon Kids Institute
• Our research
• Research Topics

Rebecca Hayley Hannah Christopher Pavlos Christian Moore Blyth RP HC HC CC PhD, MSFS, BSc (1st Class Hons), PhD W.Aust. OAM BSc (Hons) GradDipClinEpi PhD MBBS (Hons) DCH FRACP FRCPA PhD Senior Program Manager Program Head, Healthy Behaviours and ...

• 1. Telethon Kids Institute
• Projects

Traits associated with CVD, CRD and T2D in Aboriginal Australians provide novel insight into function of Arylsulphatase A Pseudodeficiency variants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Our data set provides a useful reference point for genomic studies on Aboriginal Australians ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020