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        Blinatumomab as bridging therapy in paediatric B-cell acute lymphoblastic leukaemia complicated by invasive fungal disease

        Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines recommend withholding chemotherapy to facilitate immune recovery in this setting, yet prolonged delays in leukaemia therapy increase risk of relapse. ...

        Research

        Distinct Streptococcus pneumoniae cause invasive disease in Papua New Guinea

        Streptococcus pneumoniae is a key contributor to childhood morbidity and mortality in Papua New Guinea (PNG). For the first time, whole genome sequencing of 174 isolates has enabled detailed characterisation of diverse S. pneumoniae causing invasive disease in young children in PNG, 1989-2014. ...

        Research

        Preventing severe influenza in Australian infants: Maternal influenza vaccine effectiveness in the PAEDS-FluCAN networks using the test-negative design

        Christopher Blyth CC MBBS (Hons) DCH FRACP FRCPA PhD Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases Epidemiology, Wesfarmers Centre of Vaccines and Infectious Diseases, Honorary and NHMRC Emerging ...

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        Interferon-α2b Treatment for COVID-19

        We describe here the effects of treatment with interferon-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China ...

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        Mapping Tuberculosis Prevalence in Ethiopia: Protocol for a Geospatial Meta-Analysis

        In this report, we present a protocol for a geospatial meta-analysis to investigate the spatial patterns of TB prevalence in Ethiopia ...

        Research

        Impact of the COVID-19 Pandemic on Tuberculosis Control

        Throughout history, pandemics of viral infections such as HIV, Ebola and Influenza have disrupted health care systems, including the prevention and control of endemic diseases. Such disruption has resulted in an increased burden of endemic diseases in post-pandemic periods. ...

        Research

        Exposure to bile leads to the emergence of adaptive signaling variants in the opportunistic pathogen pseudomonas aeruginosa

        Adaptive variants of P. aeruginosa that arise following long term bile exposure enables the emergence of ecologically competitive sub-populations ...

        Research

        Potential use of Western Australia’s mandatory Midwives Notification System for routinely monitoring antenatal vaccine coverage

        We observed low sensitivity and specificity of antenatal vaccination data in the Midwives Notification System ...

        Research

        Prevalence of Group A β-hemolytic Streptococcal Throat Carriage and Prospective Pilot Surveillance of Streptococcal Sore Throat in Ugandan School Children

        The Group A β-hemolytic Streptococcus pharyngeal carriage rates seen in Uganda (15.9%) are higher than the most recent pooled results globally, at 12% ...

        Research

        Public health and economic perspectives on acute rheumatic fever and rheumatic heart disease

        Efforts to eliminate ARF and RHD in Australia over the past decade have so far been unsuccessful, but this can change ...

        Research

        Impact of the “balatrine” intervention on soil-transmitted helminth infections in central Java, Indonesia: A pilot study

        The integrated BALatrine intervention was associated with a reduced incidence of soil-transmitted helminth infection ...

        Research

        Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS + Circulating T-Cells

        Our findings suggest that utilization of IL-7 by cTFH cells affects production of IgG2 antibodies to PPV23 antigens in some HIV patients ...

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