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        Stability of Pentoxifylline Injection: Application to Neonatal/Pediatric Care Setting

        Pentoxifylline (PTX) is administered as 6- or 12-hour intravenous infusions in the treatment of sepsis or necrotizing enterocolitis in neonates; however, there is a paucity of formal stability data for PTX in the end-use solution. We investigated PTX stability in the simulated clinical conditions of neonatal intensive care, where PTX injection is diluted to 5 mg/mL and administered via syringe pump. ...

        Research

        Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

        These data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course ...

        Research

        A phase IIIB, randomized, controlled, observer-blind study to evaluate safety and immunogenicity of GSK’s meningococcal ABCWY vaccine when administered in healthy adolescents and adults, previously primed with meningococcal ACWY vaccine (BOOST)

        Investigator: Peter Richmond Project description GSK is conducting a research study to evaluate its investigational, pentavalentmeningococcal vaccine, MenABCWY, which is based upon two licensed GSKmeningococcal vaccines, Menveo (MenACWY vaccine) and ...

        Research

        Interparental Conflict Across the Early Parenting Period: Evidence From Fathers Participating in an Australian Population-Based Study

        Current evidence about the prevalence of interparental conflict (IPC) during early parenthood is primarily based on mothers’ reports. Drawing upon Australian longitudinal data from 4136 fathers, the aims of the study were to report on the extent to which fathers report IPC across six biennial time intervals when their children were aged 6–12 months to 10–11 years, identify trajectories of IPC over time and identify postnatal factors (at the initial time point) associated with high risk trajectories of IPC. ...

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        Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

        Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies. ...

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        Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection

        The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and... ...

        Research

        Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

        Children of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, whereas asthma may follow a different pattern ...

        Research

        Lurasidone for Adolescents With Complex Mental Disorders: A Case Series

        Lurasidone is a new second generation (atypical) antipsychotic agent with unique receptor affinity and side-effect profiles, but limited literature is available on its use in adolescent populations. Contrasting with research treatment trials which typically recruit patients by stringent selection criteria, this case series examined the effects and tolerability of using lurasidone in adolescents within real-life clinical settings in treating complex cases who had not responded to other therapy options. We conducted a retrospective case-note audit of 6 adolescents aged 14 to 17 years old attending community child and adolescent mental health services (CAMHS) who were prescribed lurasidone. ...

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        Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

        The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood ...

        Research

        PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

        Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. ...

        Research

        Comment on "Drug discovery: Turning the titanic"

        We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways. ...

        Research

        Association between interpregnancy interval and adverse birth outcomes in women with a previous stillbirth: an international cohort study

        Conception within 12 months of a stillbirth was common and was not associated with increased risk of adverse outcomes in the subsequent pregnancy ...

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