Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the MRPP3 gene, which encodes a mitochondrial RNA processing enzyme within the RNase P complex, with predicted impact on metabolism. We used CRISPR-Cas9 genome editing to introduce this variant into the mouse Mrpp3 gene and show that the variant causes insulin resistance on a high-fat diet. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Group A streptococcus (GAS) infections, such as pharyngitis and impetigo, can lead to rheumatic fever and rheumatic heart disease (RHD). Australian Aboriginal and Torres Strait Islander populations experience high rates of RHD and GAS skin infection, yet rates of GAS pharyngitis are unclear.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

Bronchopulmonary dysplasia (BPD) remains the most common complication of preterm birth with lifelong consequences. Multiple BPD definitions are currently used in daily practice. Uniformity in defining BPD is important for clinical care, research and benchmarking. The aim of this Delphi procedure is to determine what clinicians and researchers consider the key features for defining BPD. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Whānau Pakari is a healthy lifestyle assessment and intervention programme for children and adolescents with obesity in Taranaki (Aotearoa/New Zealand), which, in this region, replaced the nationally funded Green Prescription Active Families (GRxAF) programme.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

Furthermore, previous studies suggest that scores obtained from a simplified 8-item version of the ChEDE may be more reliable and useful for research... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

A novel 18 amino acid peptide PYC98 was demonstrated to inhibit JNK1 activity toward c-Jun. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

Intramuscular administration of novel acetylated peptide-protein conjugate vaccine candidate MJ8VAX was demonstrated to be safe and immunogenic ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

This study examined the safety and immunogenicity of a vero cell culture-derived whole-virus influenza a(H5N1) vaccine in a pediatric population. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

The aim of this study was to describe clinical characteristics, outcomes and causes of microcephaly in children whose condition was identified within the first year of life. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Our aim was to identify program elements, exploring participants’ perceptions of the program's suitability, feasibility, acceptability and effectiveness. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

This review article examines risks and benefits of exposure to ultraviolet radiation for the environment and human welfare. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• May 2014

Dysphagia is an under recognised co-morbidity in patients with laryngomalacia. Its rate is variable reported in the literature. We aim to describe the incidence of dysphagia in laryngomalacia, the effect of interventions on this, and the period it persists in these infants. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022