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        Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

        Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

        Research

        Retrospective Examination of Peripubertal Return for Patients of Western Australia's Gender Diversity Service

        Children far in advance of pubertal development may be deferred from further assessment for gender-affirming medical treatment until nearer puberty. It is vital that returning peripubertal patients are seen promptly to ensure time-sensitive assessment and provision of puberty suppression treatment where appropriate. ...

        Research

        Implementation of a strategy to facilitate effective medical follow-up for Australian First Nations children hospitalised with lower respiratory tract infections: study protocol

        First Nations children hospitalised with acute lower respiratory infections (ALRIs) are at increased risk of future bronchiectasis (up to 15-19%) within 24-months post-hospitalisation. An identified predictive factor is persistent wet cough a month after hospitalisation and this is likely related to protracted bacterial bronchitis which can progress to bronchiectasis, if untreated. ...

        Research

        An immunometabolomic approach to unmask developmental regulation of innate immunity and asthma risk

        Deborah James Pat Strickland Read Holt DH JR PG PhD PhD, DSc, FRCPath, FRCPI, FAA Program Head, Immunobiology and Immunotherapeutic Program Honorary Research Associate Emeritus Honorary Researcher Deb.Strickland@telethonkids.org.au james.read@ ...

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        Review of Inclusive Preschool Program

        Yasmin Adrienne Harman-Smith Gregory YHS adrienne.gregory@telethonkids.org.au BA, BHlthSc(Hons), PhD BSocSci, MPhil Head, Early Years Systems Evidence; Head, Tenders Support Unit Project Officer Yasmin.harman-smith@telethonkids.org.au ...

        Research

        Research Note: Adaptive trials

        This Research Note has explored the strengths, risks and potential complexity of adaptive trials ...

        Research

        Western Australia Paediatric Bronchiectasis Cohort

        Kathryn André Yuliya Alana Ramsey Schultz Karpievitch Harper KR AS YK AH BSc (Hons), PhD MBChB, PhD, FRACP PhD, MS, BS BSc (hons) Co-Head, Children's Lung Health Program Head, Respiratory Health RFA Ai and Data Analytics Lead, Respiratory Research ...

        Research

        “Beacon” Cyber App Project with Bankwest

        Helen Samantha Monks Veurink H SV MPH BA(Psych) PhD BSc PostGradDip MPH Senior Project Officer Research Officer 08 6319 1470 08 6319 1492 helen.monks@telethonkids.org.au Samantha.Veurink@telethonkids.org.au Senior Research Officer Research Officer ...

        Research

        Spring-infusors: How a simple and small solution can create king-sized complexity

        The aims of the study were to investigate family and hospital staff views about the use of spring-infusor devices for administration of intravenous antibiotic medications, to examine if the device is acceptable and feasible and to map a process for implementation. ...

        Research

        Stimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndrome

        Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with complex regional pain syndrome. Activating α 1 -adrenoceptors in epidermal cells increases production of the proinflammatory cytokine interleukin-6, a mediator of inflammation. ...

        Research

        Surfactant protein disorders in childhood interstitial lung disease

        Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film. ...

        Research

        Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation

        T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

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