The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

There has been a coordinated effort from academic institutions and the PI to identify biomarkers that can predict immune checkpoint blockade response in cancer. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• May 2014

Alison McDonnell AM BSc (Hons), PhD Early Career Fellow alison.mcdonnell@telethonkids.org.au Early Career Fellow Dr Alison McDonnell is a post-doctoral scientist with a research focus in cancer immunology. Following a PhD using preclinical models of ...

• Telethon Kids Institute
• Projects

This study investigated cancer and mortality of adults exposed to blue asbestos as children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• February 2013

Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia and acute myeloid leukemia. However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Mothers of children diagnosed with cancer have been shown to experience high rates of psychological distress and poor physical health. Pregnancy further increases the healthcare needs of mothers due to the marked physiological changes and psychological adaptations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Overall cancer mortality and incidence was higher among Western Australian goldminers compared with the general male population, particularly for underground... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as little as 50 base pairs or as big as entire chromosome(s), have been associated with many congenital diseases, de novo syndromes and cancer. It is established that CNAs disturb the dosage of genomic regions including enhancers/promoters, long non-coding RNA and gene(s) among others, ultimately leading to an altered balance of key cellular functions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

The Toronto Paediatric Cancer Stage Guidelines are a compendium of staging systems developed to facilitate collection of consistent and comparable data on stage at diagnosis for childhood cancers by cancer registries. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

COVID-19 has had far-reaching impacts including changes in work, travel, social structures, education, and healthcare. This study aimed to explore the experiences of parents of children receiving treatment for cancer during the COVID-19 pandemic. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022