This novel approach aimed to prevent inflated hazard ratios arising from reverse causation, and allow identification of associations beyond those already... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

Overall cancer mortality and incidence was higher among Western Australian goldminers compared with the general male population, particularly for underground... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia and acute myeloid leukemia. However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Mothers of children diagnosed with cancer have been shown to experience high rates of psychological distress and poor physical health. Pregnancy further increases the healthcare needs of mothers due to the marked physiological changes and psychological adaptations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

This study investigated cancer and mortality of adults exposed to blue asbestos as children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• February 2013

Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

There has been a coordinated effort from academic institutions and the PI to identify biomarkers that can predict immune checkpoint blockade response in cancer. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• May 2014

Alison McDonnell AM BSc (Hons), PhD Early Career Fellow alison.mcdonnell@telethonkids.org.au Early Career Fellow Dr Alison McDonnell is a post-doctoral scientist with a research focus in cancer immunology. Following a PhD using preclinical models of ...

• Telethon Kids Institute
• Projects