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        Lessons learned in genetic research with Indigenous Australian participants

        We reflect on the lessons learned from a recent genome‐wide association study of rheumatic heart disease with Aboriginal Australian participants ...

        Research

        Indigenous Australian genomes show deep structure and rich novel variation

        The Indigenous peoples of Australia have a rich linguistic and cultural history. How this relates to genetic diversity remains largely unknown because of their limited engagement with genomic studies. Here we analyse the genomes of 159 individuals from four remote Indigenous communities, including people who speak a language (Tiwi) not from the most widespread family (Pama-Nyungan). This large collection of Indigenous Australian genomes was made possible by careful community engagement and consultation. ...

        Research

        The landscape of genomic structural variation in Indigenous Australians

        Indigenous Australians harbour rich and unique genomic diversity. However, Aboriginal and Torres Strait Islander ancestries are historically under-represented in genomics research and almost completely missing from reference datasets. Addressing this representation gap is critical, both to advance our understanding of global human genomic diversity and as a prerequisite for ensuring equitable outcomes in genomic medicine. ...

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        Occurrence and timely management of problems requiring prompt intervention among Indigenous compared with non-Indigenous Australian palliative care patients: A multijurisdictional cohort study

        Anticipation and prompt relief of symptoms among patients with a life-limiting illness is a core element of palliative care. Indigenous Australians commonly encounter cultural barriers in healthcare that may impair outcomes. The Palliative Care Outcomes Collaboration collects patient care data for the purposes of continuous quality improvement and benchmarking, with each recorded care episode divided into phases that reflect a patient's condition. ...

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        Resilience, renewal and hope in Australian Indigenous-led primary health care initiatives

        Citation: Marriott R, Reibel T. Resilience, renewal and hope in Australian Indigenous-led primary health care initiatives. Prim Health Care Res Dev. 2021;22. ...

        Research

        Socioeconomic disparities in the mental health of Indigenous children in Western Australia

        The burden of mental health problems among Aboriginal and Torres Strait Islander children is a major public health problem in Australia. ...

        Research

        Theories of otitis media pathogenesis, with a focus on Indigenous children

        Otitis media is a common childhood illness associated with hearing loss, social disadvantage and medical costs. Prevalence and severity are high among... ...

        Research

        Improving delivery of secondary prophylaxis for rheumatic heart disease in remote Indigenous communities

        This trial aims to improve uptake of secondary prophylaxis among Aboriginal people with ARF/RHD to reduce progression or worsening of RHD. ...

        Research

        Increased mortality among Indigenous persons during and after release from prison in New South Wales

        The objective of this study was to estimate the overall and cause specific mortality of Aboriginal offenders in New South Wales (NSW), Australia. ...

        Research

        Increasing incidence of invasive group A streptococcal disease in Western Australia, particularly among Indigenous people

        The incidence of invasive GAS disease in WA increased between 2000 and 2018, particularly among Indigenous Australians. Mandatory notification of invasive GAS disease would therefore be appropriate. The social determinants of differences in incidence should be addressed, and other relevant host, pathogen, and health system factors investigated. ...

        Research

        PneuMum: Impact from a trial of maternal pneumococcal vaccination on middle ear disease amongst Indigenous infants

        This study was unable to demonstrate efficacy of 23vPPV in pregnancy against the co-primary outcomes of either all-cause infant ear disease. ...

        Research

        Rheumatic heart disease in Indigenous children in northern Australia: Differences in prevalence and the challenges of screening

        This study compared regional differences in the prevalence of rheumatic heart disease in Indigenous Australian children, and describes the logistical and... ...

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