Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Early life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

We systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

Exposure to elevated maternal pre-pregnancy BMI is associated with increased levels of internalizing and externalizing problems throughout childhood and... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• March 2013

Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Reliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

To identify links between drug resistance and gene deregulation we used oligonucleotide microarray technology. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012

New research links poor language to lack of Vitamin D in womb. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

This report will outline the theory and evidence base for Community Development and Community Engagement, report on consultation activities and findings ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• June 2016