Browse study websites

Discover. Prevent. Cure.

Menu Fundraise Donate

    Recommended pages

      Do you mean

        37-48 of 147 results

        Refine research

        Research

        Reversibility of trapped air on chest computed tomography in cystic fibrosis patients

        To investigate changes in trapped air volume and distribution over time and compare computed tomography (CT) with pulmonary function tests for determining... ...

        Research

        SYNERGY CF: Getting the best start to life - preventing early cystic fibrosis lung disease by solving the host-inflammation infection conundrum

        Anthony Stephen Yuliya Kicic Stick Karpievitch A SM YK BSc (Hons) PhD MB BChir PhD MRCP FRACP PhD, MS, BS Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory Health for Kids Ai and Data Analytics Lead, Respiratory Research ...

        Research

        The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis

        In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.  ...

        Research

        Azithromycin reduces bronchial wall thickening in infants with cystic fibrosis

        COMBAT-CF showed that children aged 0-3 years treated with azithromycin did clinically better than placebo but there was no effect on CT-scores. We reanalysed CTs using an automatic bronchus-artery (BA) analysis. ...

        Research

        Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis

        Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by increases in both mucin and DNA concentration. Additionally, it has been shown that half of the mucins present in bronchial alveolar lavage fluid from preschool-aged CF patients are present in as non-swellable mucus flakes. ...

        Research

        Systems biology and bile acid signalling in microbiome-host interactions in the cystic fibrosis lung

        The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis. ...

        Research

        Lung inflammation and simulated airway resistance in infants with cystic fibrosis

        Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. ...

        Research

        BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis

        Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid? ...

        Research

        Early disease surveillance in young children with cystic fibrosis: A qualitative analysis of parent experiences

        Sensitive measures of early lung disease are being integrated into therapeutic trials and clinical practice in cystic fibrosis (CF). The impact of early disease surveillance (EDS) using these novel and often intensive techniques on young children and their families is not well researched. ...

        Research

        Assessment of early lung disease in young children with CF: A comparison between pressure-controlled and free-breathing chest computed tomography

        Our data suggest that FRC PC-CTs are less sensitive than TLC PC-CTs and that FB-CTs have similar sensitivity to PC-CTs in detecting lung disease ...

        Research

        Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease

        Several lipid biomarkers of early cystic fibrosis lung disease were identified, which point toward potential disease monitoring and therapeutic approaches ...

        Research

        The potential of phage therapy in cystic fibrosis

        This review summarises the phage-microbe-human lung interactions in CF that must be addressed to successfully develop and deliver phage to CF airways ...

        Page 4 of 13