We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

The ANZSRS recommends the adoption of the Global Lung Function Initiative (GLI) 2012 spirometry reference values throughout Australia and New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Despite advances in neonatal intensive care, babies admitted to Neonatal Intensive Care Units (NICU) suffer from adverse outcomes. We aim to describe the longer-term respiratory infectious morbidity of infants discharged from NICU using state-wide population-based linked data in Western Australia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Preterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

Exhaled breath temperature (EBT) has been proposed for the non-invasive assessment of airway inflammation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

To describe the changes in end-expiratory lung volume and ventilation inhomogeneities during spells in three children with Tetralogy of Fallot. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

This study investigated the nature and prevalence of atypical pain responses in Rett syndrome and their relationships with specific MECP2 mutations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

The ANZSRS recommends the adoption of the Global Lung Function Initiative (GLI) 2012 spirometry reference values throughout Australia and New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

The present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

We screened for risk factors from children's and their families' histories, and assessed the usefulness of common markers of allergic sensitisation of the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014