The aim of our investigation was to assess the chemical composition of a range of e-liquids available in Australia, focusing on nicotine and other potentially harmful compounds ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

The rat model demonstrates that intrauterine growth restriction leads to a more heterogeneous distribution of airway lumen calibre in adulthood ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• October 2017

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

This work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Exposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

• 1. Telethon Kids Institute
• Projects

Alexander David Deborah Larcombe Martino Strickland A DM DH BScEnv (Hons) PhD BSc PhD PhD Team Leader, Respiratory Environmental Health Head, Clinical Epigenetics Program Head, Immunobiology and Immunotherapeutic Program David.Martino@ ...

• 1. Telethon Kids Institute
• Projects

Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

Electronic cigarettes (e-cigarettes) lack regulatory status as therapeutic products in all jurisdictions worldwide. They are potentially unsafe consumer products, with significant evidence they pose a risk to human health. Therefore, developing rapid, economical test methods to assess the chemical composition of e-liquids in heated and unheated forms and the aerosols produced by e-cigarettes is crucial. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021