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        Level of purposeful hand function as a marker of clinical severity in Rett syndrome

        Helen Peter Leonard Jacoby HM PJ MBChB MPH BA (Hons) MSc Principal Research Fellow Biostatistician +61 419 956 946 helen.leonard@telethonkids.org.au Peter.Jacoby@telethonkids.org.au Principal Research Fellow Biostatistician Authors: Downs J, ...

        Research

        Smoking cessation in pregnancy and the risk of child behavioural problems: a longitudinal prospective cohort study

        The aim of this study was to examine the influence of smoking in pregnancy on child and adolescent behavioural development, in comparison with mothers who cease ...

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        Nothing but fear itself: parental fear as a determinant of child physical activity and independent mobility

        Over the past decade we have seen declining rates in child engagement in physical activity with escalating health problems ensuing. ...

        Research

        The broader language phenotype of Autism: A comparison with Specific Language Impairment

        Some individuals with autism spectrum disorders (ASD) experience linguistic difficulties similar to those found in individuals with specific language... ...

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        Lost in translation: translational interference from a recurrent mutation in exon 1 of MECP2

        Rett syndrome (RTT) is an X linked neuro-developmental disorder affecting mostly girls. Mutations in the coding region of MECP2 are found in 80% of classic... ...

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        Exploring indoor and outdoor dust as a potential tool for detection and monitoring of COVID-19 transmission

        This study investigated the potential of using SARS-CoV-2 viral concentrations in dust as an additional surveillance tool for early detection and monitoring of COVID-19 transmission. Dust samples were collected from 8 public locations in 16 districts of Bangkok, Thailand, from June to August 2021. ...

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        qPCR assay optimisation for a clinical study comparing oral health risk in Rett syndrome

        This study aimed to validate qPCR assays for specific microbiota, for use on dental plaque samples stored on Whatman FTA cards to compare relative oral health risk in Rett syndrome. ...

        Research

        Prolonged Grief Disorder, but Not Death From COVID-19, Elicits Public Stigma: A Vignette-Based Experiment

        We investigated the effects of cause of death (COVID-19 with an underlying medical condition vs. without) and prolonged grief disorder status (PGD present or absent) on participants' reported public stigma towards the bereaved. ...

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        Parents’ attitudes towards the No Jab No Play legislation in Western Australia: a mixed methods study

        Mandates provide a relatively cost-effective strategy to increase vaccinate rates. Since 2014, five Australian states have implemented No Jab No Play (NJPlay) policies that require children to be fully immunised to attend early childhood education and childcare services. In Western Australia, where this study was conducted, NJNPlay legislation was enacted in 2019.  ...

        Research

        A Maximum Entropy Model of the Distribution of Dengue Serotype in Mexico

        Pathogen strain diversity is an important driver of the trajectory of epidemics. The role of bioclimatic factors on the spatial distribution of dengue virus serotypes has, however, not been previously studied. Hence, we developed municipality-scale environmental suitability maps for the four dengue virus serotypes using maximum entropy modeling. ...

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        Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis

        Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-risk age-group for respiratory infections, remain unclear. We conducted a systematic review and meta-analysis of epidemiological and clinical characteristics of COVID-19 infection in children under five years. ...

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        Questionnaires Measuring Physical Activity in Clinical Pediatric Populations: A Systematic Review

        Regular physical activity (PA) is a cornerstone therapy for many childhood chronic health conditions, and questionnaires offer a simple method for monitoring PA and identifying children who do not meet clinical practice guidelines. The purpose of this systematic review is to determine which questionnaires are most efficacious for assessing PA in children with chronic health conditions. ...

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