Multimodal analgesia is employed in paediatric pain management to maximise analgesia and minimise side effects. Tramadol is dosed at 1–1.5 mg/kg to treat severe pain in children but the assay for tramadol in plasma samples for pharmacokinetic and toxicology studies does not often consider concurrently administered medications. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Little is known about how to effectively encourage higher levels of activity among older people. This study tested the effectiveness of a public service advertisement designed according to recommendations for communicating with older audiences and featuring five types of moderate-to-vigorous physical activity: tennis, line dancing, cycling, swimming and jogging. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. Methods: National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

To explore the perceptions of parents who had a child or adolescent (6-18 years) diagnosed with a rare disease who attended a mainstream school in Western Australia. Design and methods: A cross-sectional online survey was conducted with 41 parents of children with a rare disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

The climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Genetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from diverse prokaryal genomes to screen MMIs promoting the nuclear relocalization of Forkhead Box O3 (FOXO3a), a tumor suppressor more frequently inactivated by post-translational modification than mutation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Repeated video instruction over time improves inhaler technique in young children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

The role of HOXD10 in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

These findings will facilitate harmonization of data and collaborative research efforts, which are so necessary on account of the heterogeneity and... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

A targeted program would have the potential to prevent one-quarter of the cases of being vulnerable on two or more AEDC domains at age five ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Soft neurological signs were more common in children with prenatal alcohol exposure or FASD, consistent with the known neurotoxic effect of PAE ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Development of an instrument to assess women's perception of their entire maternity-care experience ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016