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        Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population

        Otitis media (OM) is a common disease in early childhood characterised by inflammation of the middle ear. ...

        Research

        Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood

        We identified several novel candidate genes which warrant further analysis in cohorts matched more precisely for clinical phenotypes. ...

        Research

        The effects of sleep duration on child health and development

        Children and adolescents spend more than one-third of their time sleeping. Yet, we know little about the causal impact of sleeping on their development. This paper is the first to exploit variation in local daily daylight duration measured on pre-determined diary dates across the same individuals through time as an instrument in an individual fixed effects regression model to draw causal estimates of sleep duration on a comprehensive set of child development indicators.  ...

        Research

        Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

        Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

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        Genetic Research and Aboriginal and Torres Strait Islander Australians

        Human genetic research promises to deliver a range of health benefits to the population. Here we consider how the different levels of Indigenous research... ...

        Research

        Development and validation of the Australian Aboriginal racial identity and self-esteem survey for 8-12 year old children (IRISE-C)

        In Australia, there is little empirical research of the racial identity of Indigenous children and youth as the majority of the current literature focuses on... ...

        Research

        Children's neighbourhood physical environment and early development: an individual child level linked data study

        The neighbourhood physical environment has a weak but significant association with early childhood development ...

        Research

        Health service utilisation for acute respiratory infections in infants graduating from the neonatal intensive care unit: a population-based cohort study

        Despite advances in neonatal intensive care, babies admitted to Neonatal Intensive Care Units (NICU) suffer from adverse outcomes. We aim to describe the longer-term respiratory infectious morbidity of infants discharged from NICU using state-wide population-based linked data in Western Australia. ...

        Research

        Mitochondrial Gene Therapy

        Aleksandra Filipovska AF BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for Synthetic Biology; Adjunct Research Professor, Monash University Louis Landau Chair in Child Health ...

        Research

        Development of Resources for Schools – Responding to and Planning for Children with Complex and Challenging Behaviours

        Yasmin Lizzie Harman-Smith Button YHS LB BA, BHlthSc(Hons), PhD BPsych (Hons) Head, Early Years Systems Evidence; Head, Tenders Support Unit Research Assistant 08 6375 9747 Yasmin.harman-smith@telethonkids.org.au elizabeth.button@ ...

        Research

        Bacterial and Fungal Gut Community Dynamics Over the First 5 Years of Life in Predominantly Rural Communities in Ghana

        Bacterial and fungal microbiotas are increasingly recognized as important in health and disease starting early in life. However, microbiota composition has not yet been investigated in most rural, low-resource settings, and in such settings, bacterial and fungal microbiotas have not been compared. ...

        Research

        Acute Lymphoblastic Leukemia in Infants: A Distinctive, High-Risk Subtype of Childhood Acute Lymphoblastic Leukemia

        Acute lymphoblastic leukemia (ALL) in infants younger than 1 year of age is an aggressive, high-risk subtype of childhood ALL. Infant ALL with KMT2A-r is characteristically poorly responsive to chemotherapy and hematopoietic stem cell transplantation. New strategies, such as molecularly targeted therapies and immunotherapies, are in development and show promise in preclinical models and early phase studies. ...

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