We investigated whether a commonly used research assessment - the Autism Observation Scale for Infants (AOSI) - accurately measures autism behaviours among infants showing early signs of autism identified within the community. The AOSI is often included in studies tracking the development of infants at increased likelihood of autism, such as the infant siblings of diagnosed children. However, the suitability of this measure has not previously been tested with community-referred infants. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

This study highlights a range of unique profiles that can be used for improving the early development of young Aboriginal children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Attention Deficit/hyperactivity disorder (ADHD) is conceptualized differently in the Diagnostic and Statistical Manual (DSM-5), the International Classification of Diseases-10 (ICD-10), and the Hierarchical Taxonomy of Psychopathology (HiTOP) frameworks. This study applied independent cluster confirmatory factor analysis (ICM-CFA), exploratory structure equation model with target rotation (ESEM), and the S-1 bi-factor CFA approaches to evaluate seven ADHD models yielded by different combinations of these taxonomic frameworks. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Leaders from the Canadian Society for Exercise Physiology convened national representatives to create the C24 movement for Children and Youth. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

This study assessed the functional skills of three girls with RTT aged 35 years before and during participation in a CE programme. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

There are limited psychometric data on outcome measures for children with Developmental Epileptic Encephalopathies (DEEs), beyond measuring seizures, and no data to describe meaningful change. This study aimed to explore parent perceptions of important differences in functional abilities that would guide their participation in clinical trials. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

The importance of play for a child’s development is irrefutable. Playgroups provide a safe environment for children of similar ages to play and develop prior to starting school. ...

• 1. Telethon Kids Institute
• Our research
• Research Topics

Carol Bower C MBBS MSc PhD FAFPHM DLSHTM FPHA Senior Principal Research Fellow, Alcohol and Pregnancy & FASD Research; Director, FASD Research Australia CRE 08 6319 1813 carol.bower@telethonkids.org.au Senior Principal Research Fellow; Director, ...

• 1. Telethon Kids Institute
• Projects

The climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

The rebuilding of trust requires the development of meaningful relationships in order to break down the barriers so as to increase access and develop culturally secure responses by services ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• July 2016