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        A large proportion of poor birth outcomes among Aboriginal Western Australians are attributable to smoking, alcohol and substance misuse, and assault

        A large proportion of adverse outcomes were attributable to the modifiable risk factors of substance use and assault ...

        Research

        The dystroglycan receptor maintains glioma stem cells in the vascular niche

        These findings reveal a central role of the DG receptor, not only as a structural element, but also as a critical factor promoting mesenchymal-like GBM ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Potassium Ion Channels in Malignant Central Nervous System Cancers

        Malignant central nervous system (CNS) cancers are among the most difficult to treat, with low rates of survival and a high likelihood of recurrence. This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. ...

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        Developing and characterising juvenile models of aggressive paediatric brain cancers for the evaluation of novel immunotherapies

        Nick Raelene Terrance Gottardo Endersby Johns NG R T MBChB FRACP PhD BSc (Hons) PhD Co-Head, Brain Tumour Research Brainchild Fellow; Co-Head, Brain Tumour Research Honorary Research Associate nicholas.gottardo@telethonkids.org.au raelene.endersby@ ...

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        Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study

        This genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels... ...

        Research

        Sore Throat Melbourne and Perth Study: The Australian Strep A Vaccine Initiative (ASAVI) Urban Pharyngitis Surveillance Study (STAMPS)

        Jonathan Peter Carapetis AM Richmond JR PC AM MBBS FRACP FAFPHM PhD FAHMS MBBS MRCP(UK) FRACP Executive Director; Head, Strep A Translation; Co-Founder of REACH Head, Vaccine Trials Group 08 6319 1000 contact@telethonkids.org.au Institute Director; ...

        Research

        Expression of bronchodilator response using forced oscillation technique measurements: absolute versus relative

        Expression of bronchodilator response using forced oscillation technique measurements: absolute versus relative ...

        Research

        Complexity of Influenza Outbreaks during the World Youth Day 2008 Mass Gathering and its Impact on Community Seasonal Influenza Activity

        How Influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. ...

        Research

        Skull base osteomyelitis: Fungal versus Bacterial Infection

        An 18-year (1990-2007) retrospective review of patients with Skull-base osteomyelitis (SBO) presenting to Westmead Hospital was performed. ...

        Research

        Independent effects of socioeconomic status and place of residence on the incidence of type 1 diabetes in Western Australia

        To analyze the incidence of type 1 diabetes in 0- to 14-year olds in Western Australia, from 1985 to 2002, by region and socioeconomic status. ...

        Research

        Severe hypoglycemia rates are not associated with HbA1c: A cross-sectional analysis of 3 contemporary pediatric diabetes registry databases

        To examine the association between glycated hemoglobin (HbA1c) and severe hypoglycemia rates in patients with type 1 diabetes receiving usual care. ...

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