Vitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Characterization of the complete IgE binding spectrum of cat allergens is important for the development of improved diagnosis and effective immunotherapeutics. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

To evaluate the suitability of the Global Lung Function Initiative (GLI)-2012 other/mixed and GLI-2022 global reference equations for evaluating the respiratory capacity of First Nations Australians.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

The authors previously reported an increased risk of hospitalisation for acute lower respiratory infection up to age 2 years in children delivered by... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• May 2012

The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• October 2009

We aimed to ascertain the fit of the European Respiratory Society Global Lung Initiative 2012 reference ranges to contemporary Australasian spirometric data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• October 2012

Survivors of CDH may have significant adverse long-term medical and psychosocial issues that would be better recognised and managed in a multidisciplinary clinic ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and function are unknown. Suppressor of cytokine signaling (SOCS)1 and SOCS3 block STAT3, and low SOCS1 levels have been reported in IPF fibroblasts and shown to facilitate collagen production. Fibroblasts and lung tissue from IPF patients and controls were used to examine the mechanisms underlying SOCS1 down-regulation in IPF. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Our findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Newborn screening (NBS) for cystic fibrosis (CF) provides an opportunity to commence management and therapeutic interventions significantly earlier ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

The pathophysiology of BPD has changed in recent years as advances in neonatal care have led to increased survival of smaller, more preterm, infants who... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015