Jonathan Carapetis AM JR AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@telethonkids.org.au Institute Director; Head, Strep A Translation; Co-Founder of REACH Professor ...

• Telethon Kids Institute
• Projects

Early life infections drive high antibiotic prescribing rates in remote Aboriginal communities ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Prevalence of skin sores and scabies in remote Australian Aboriginal communities remains unacceptably high, with Group A Streptococcus (GAS) the dominant pathogen. We aim to better understand the drivers of GAS transmission using mathematical models. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

Breastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• July 2011

There has been a dramatic increase in the availability of "routine data" for research purposes, including data from electronic medical records,... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• August 2010

The vascular endothelial growth factors and their receptors are key regulators of blood vessel formation, including in tumors, where their deregulated function can promote the production of aberrant, leaky blood vessels, supporting tumor development.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

Population-level studies of severe pertussis extending beyond infancy are sparse, and none in the context of antenatal vaccination. We compared hospitalized pertussis cases from birth to 15 years of age before and after introduction of antenatal immunization. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022