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        Mapping Tuberculosis Prevalence in Ethiopia: Protocol for a Geospatial Meta-Analysis

        In this report, we present a protocol for a geospatial meta-analysis to investigate the spatial patterns of TB prevalence in Ethiopia ...

        Research

        Public health and economic perspectives on acute rheumatic fever and rheumatic heart disease

        Efforts to eliminate ARF and RHD in Australia over the past decade have so far been unsuccessful, but this can change ...

        Research

        Parental experiences using the Therapy Outcomes by You (TOBY) application to deliver early intervention to their child with autism

        Parental experience of TOBY was positive when use of the application aligned with parental proficiency, opportunities for use, and importantly, the needs of the child ...

        Research

        Factors Associated With 90-Day Readmission After Stroke or Transient Ischemic Attack: Linked Data From the Australian Stroke Clinical Registry

        Apart from comorbidities and patient-level characteristics, readmissions after stroke/transient ischemic attack were associated with discharge destination ...

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        The associations between autistic and communication traits in parents and developmental outcomes in children at familial risk of autism at 6 and 24 months of age

        Several studies have explored relationships between parent broader autism phenotype and offspring communication, and have reported that autistic-like traits in parents are related to offspring communication difficulties and autism severity. However, past research has focused on studying such associations in childhood and we know very little about them in infancy. With accumulating evidence that interventions administered during infancy may be most effective in reducing ASD symptoms, it is imperative to examine whether relationships between parent autistic-like traits and child communication appear even earlier during this critical period of life. ...

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        A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

        Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab. ...

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        Comparison of group A streptococcal titres in healthy children and those with pharyngitis and skin infections

        Rates of acute rheumatic fever, a sequelae of group A Streptococcal (GAS) infection, remain unacceptably high in Indigenous Māori and Pacific children in New Zealand. This prospective study aimed to describe GAS antibody titres in healthy children (5–14 years) by ethnicity, and to determine how paired titres vary with GAS culture positive and negative pharyngitis, and GAS skin infections. ...

        Research

        Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank

        Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose biological basis is yet to be elucidated. The Australian Autism Biobank (AAB) is an initiative of the Cooperative Research Centre for Living with Autism (Autism CRC) to establish an Australian resource of biospecimens, phenotypes and genomic data for research on autism. ...

        Research

        Global epidemiology of valvular heart disease

        Valvular heart disease is a major contributor to loss of physical function, quality of life and longevity. The epidemiology of VHD varies substantially around the world, with a predominance of functional and degenerative disease in high-income countries, and a predominance of rheumatic heart disease in low-income and middle-income countries. Reflecting this distribution, rheumatic heart disease remains by far the most common manifestation of VHD worldwide and affects approximately 41 million people. ...

        Research

        Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

        The age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average. ...

        Research

        A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.

        This publication is a systematic analysis of all Group A Streptococcus M protein variants, to assist in the development of a vaccine. ...

        Research

        Invasive group A streptococcal infection in the Northern Territory, Australia: Case report and review of the literature

        This review article presents the case of infant Aboriginal twins with invasive group A streptococcal infection complicated by streptococcal toxic shock... ...

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