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        Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency

        are oxidative stress or glutathione status associated with brochiectasis and whether glutathione deficiency is inherently linked to CF or from oxidative stress ...

        Research

        Airway IRF7hi versus IRF7lo molecular response patterns determine clinical phenotypes in children with acute wheezing

        We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. ...

        Research

        Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expression

        Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei. ...

        Research

        The global lung function initiative (GLI) network: Bringing the world’s respiratory reference values together

        The Global Lung Function Initiative (GLI) Network has become the largest resource for reference values for routine lung function testing ever assembled. ...

        Research

        Breastfeeding beyond the big smoke: Who provides support for mothers in rural Western Australia?

        Antenatal group education is effective in supporting breastfeeding duration for rural women and should be a key priority for rural health service providers. ...

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        High-dose intramuscular Vitamin D provides long-lasting moderate increases in serum 25-hydroxVitamin D levels and shorter-Term changes in plasma calcium

        Intramuscular injection of a large bolus of Vitamin D effectively increases serum 25-hydroxyVitamin D levels without evidence of metabolic abnormality. ...

        Research

        The bioenergetics of inflammation: insights into obesity and type 2 diabetes

        Diabetes mellitus is one of the most common chronic metabolic disorders worldwide, and its incidence in Asian countries is alarmingly high. ...

        Research

        UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

        A systemic immunosuppression follows UV irradiation of the skin of humans and mice. ...

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        An exposome perspective: Early-life events and immune development in a changing world

        Here we review the historical origins of exposome research and define a new concept, the metaexposome ...

        Research

        Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis

        This study aimed to determine the relationship between ULDCT-ILD and measures of pulmonary function in an asbestos-exposed population. ...

        Research

        Infant feeding and growth trajectory patterns in childhood and body composition in young adulthood

        Full breastfeeding for <3 months compared with ≥3 months may be associated with rapid growth in early childhood and body composition in young adulthood ...

        Research

        Clonal expansion of new penicillin-resistant clade of neisseria meningitidis serogroup w clonal complex 11, Australia

        In Western Australia, Neisseria meningitidis serogroup W clonal complex 11 became the predominant cause of invasive meningococcal disease in 2016 ...

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