The aim of the current study was to determine how carer needs changed longitudinally and understand associations between unmet needs and distress. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

This is the first study to examine the associations between a range of blood micronutrient levels and DNA damage in healthy children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015

Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukaemia (ALL). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individually and combinatorially. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

The mitochondrial genome encodes core subunits of the respiratory chain that drives oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in high-throughput sequencing technologies and cryoelectron microscopy have shed light on the structure and organization of the mitochondrial genome and revealed unique mechanisms of mitochondrial gene regulation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022

The evolutionary acquisition of mitochondria has given rise to the diversity of eukaryotic life. Mitochondria have retained their ancestral α-proteobacterial traits through the maintenance of double membranes and their own circular genome. Their genome varies in size from very large in plants to the smallest in animals and their parasites. The mitochondrial genome encodes essential genes for protein synthesis and has to coordinate its expression with the nuclear genome from which it sources most of the proteins required for mitochondrial biogenesis and function. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Research priority setting activities in paediatric chronic disease cover many discipline areas and have elicited a broad range of topics ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

We conclude that the novel chocolate-based formulation of midazolam provides improved tolerability while remaining efficacious ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

Growing evidence supports a role for infection in the etiology of ALL and the involvement of immune systems suggests that vaccination may also play a role. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

A simple, clinically relevant model to reliably discriminate patients at high and lower risk of death in patients with malignant pleural mesothelioma ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• April 2016

Higher levels of paternal dietary vitamin B12 were appeared to be associated with an increased risk of childhood ALL, with those in the highest tertile of... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014