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        Exploring clonal diversity in paediatric B-cell leukaemia to identify new therapeutic weakness

        Sébastien Rishi Sury Laurence Timo Malinge Kotecha Cheung Lassmann SM RS LC T PhD MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD BSc (Hons) MSc PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

        Research

        Pathways between racial discrimination and the health and wellbeing of Aboriginal and Torres Strait Islander children and young people

        Carrington Steve Shepherd Zubrick CCJ SR PhD FASSA, FAAMHS, MSc AM PhD Honorary Research Associate Honorary Emeritus Research Fellow 08 6319 1409 Stephen.zubrick@telethonkids.org.au Honorary Research Associate Honorary Emeritus Research Fellow Areas ...

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        Understanding the true burden of paediatric respiratory syncytial virus (RSV) in order to optimise prevention programs

        Hannah Moore HC OAM BSc (Hons) GradDipClinEpi PhD Program Head, Infection and Vaccines 08 6319 1427 Hannah.moore@telethonkids.org.au Program Head, Infection and Vaccines A/Prof Hannah Moore OAM is Program Head, Infections and Vaccines at the ...

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        Adaption and implementation of Aboriginal child lung health tools for northern Western Australia

        André Schultz AS MBChB, PhD, FRACP Program Head, Respiratory Health RFA Program Head, Respiratory Health RFA Prof André Schultz is the Program Head of Respiratory Health and Head of the BREATH Team at Telethon Kids Institute. He is passionate ...

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        Evaluation of the Learning+ Pilot Program

        Yasmin Adrienne Harman-Smith Gregory YHS adrienne.gregory@telethonkids.org.au BA, BHlthSc(Hons), PhD BSocSci, MPhil Head, Early Years Systems Evidence; Head, Tenders Support Unit Project Officer Yasmin.harman-smith@telethonkids.org.au ...

        Research

        Intranasal Insulin Trial II

        Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research Co-head, Diabetes and Obesity Research Head, Chronic & Severe Diseases Research Focus Area; ...

        Research

        Challenges and considerations for antifungal prophylaxis in children with acute myeloid leukemia

        Children receiving treatment for acute myeloid leukemia (AML) are at high risk of invasive fungal disease (IFD). Evidence from pediatric studies support the efficacy of antifungal prophylaxis in reducing the burden of IFD in children receiving therapy for AML, yet existing antifungal agents have specific limitations and comparative data to inform the optimal prophylactic approach are lacking. ...

        Research

        Identifying barriers and facilitators for the effective diagnosis and provision of primary health care for otitis media from the perspective of carers of Aboriginal children

        To identify the barriers and facilitators for timely detection and optimal management of otitis media in Aboriginal children in a primary care setting from the perspective of carers of Aboriginal children.  ...

        Research

        Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia

        PEGasparaginase is known to be a critical drug for treating pediatric acute lymphoblastic leukemia (ALL), however, there is insufficient evidence to determine the optimal dose for infants who are less than one year of age at diagnosis. This international study was conducted to identify the pharmacokinetics of PEGasparaginase in infants with newly diagnosed ALL and gather insight into the clearance and dosing of this population. ...

        Research

        Burden of drug-resistant tuberculosis among contacts of index cases: A protocol for a systematic review

        People having close contact with drug-resistant tuberculosis (DR-TB) patients are at increased risk of contracting and developing the disease. However, no comprehensive review has been undertaken to estimate the burden of DR-TB among contacts of DR-TB patients. Therefore, the current systematic review will quantify the prevalence and incidence of DR-TB among contacts of DR-TB patients. ...

        Research

        Comparative effectiveness of interventions for preventing tuberculosis: systematic review and network meta-analysis of interventional studies

        Tuberculosis (TB) is the leading infectious cause of death globally. Several preventive measures are employed to prevent TB, yet there is a paucity of evidence on the effectiveness of these interventions. Therefore, this study aimed to identify the most effective interventions for reducing TB incidence. ...

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