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        A platform in the use of medicines to treat chronic hepatitis C (PLATINUM C): protocol for a prospective treatment registry of real-world outcomes for hepatitis C

        Safe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatitis C virus (HCV) in Australia. If left untreated, hepatitis C may lead to progressive hepatic fibrosis, cirrhosis and hepatocellular carcinoma. ...

        Research

        Prenatal alcohol and tobacco use and the risk of depression in offspring at age of 17 years: findings from the Raine Study

        Prenatal alcohol and tobacco exposures have been associated with adverse mental health consequences in offspring. The objective of this study was to test the associations between maternal prenatal alcohol and tobacco exposures and depressive symptoms in the offspring, adjusting for a wide range of potential confounders. ...

        Research

        Meta-analysis of the neural correlates of vigilant attention in children and adolescents

        Vigilant Attention (VA), defined as the ability to maintain attention to cognitively unchallenging activities over a prolonged period of time, is critical to support higher cognitive functions and many behaviours in our everyday life. Evidence has shown that VA rapidly improves throughout childhood and adolescence until young adulthood and tends to decline in older adulthood. ...

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        Tackling the Burden of Osteoarthritis as a Health Care Opportunity in Indigenous Communities-A Call to Action

        Osteoarthritis is a highly prevalent and disabling disease, causing a significant individual and socioeconomic burden worldwide. Until now, there has been a dearth of research exploring the impact of osteoarthritis in global Indigenous communities. ...

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        Developmental outcomes following vaccine-proximate febrile seizures in children

        To compare the developmental and behavioral outcomes of children experiencing an initial vaccine-proximate (VP) febrile seizure (FS) to those having a non-VP-FS (NVP-FS) and controls who have not had a seizure. ...

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        Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants

        Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese immigrants, which fails to prime the immune system. Here, we investigated how differences in composition of oropharyngeal microbiome may contribute to patterns of interaction between the microbiome and immune system in Chinese immigrants living in Australia. ...

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        The risk of intramuscular haematoma is low following injection of benzathine penicillin G in patients receiving concomitant anticoagulant therapy

        Our local data supports continuing intramuscular injection of BPG in patients with rheumatic heart disease receiving anticoagulant medication ...

        Research

        Measuring early child development in low and middle income countries: Investigating the validity of the early Human Capability Index

        Inclusion of early child development in the United Nations Sustainable Development Agenda raises issues of how this goal should be monitored, particularly in low resource settings. The aim of this paper was to explore the validity of the early Human Capability Index (eHCI); a population measure designed to capture the holistic development of children aged 3-5 years. Convergent, divergent, discriminant and concurrent validity were examined by exploring the associations between eHCI domains and child (sex, age, stunting status, preschool attendance) and family (maternal education, home learning environment) characteristics. Analyses were repeated using data from seven low and middle income countries. ...

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        Complicated skin and soft tissue infections in remote indigenous communities

        The burden and consequences of skin infections for remote living indigenous people are high ...

        Research

        How outreach facilitates family engagement with universal early childhood health and education services in Tasmania, Australia: An ethnographic study

        This paper presents qualitative findings focusing on the scope and role of outreach in supporting family engagement in the Tasmanian early childhood services ...

        Research

        Azithromycin Partially Mitigates Dysregulated Repair of Lung Allograft Small Airway Epithelium

        Chronic airway injury and dysregulated repair programs are evident in airway epithelium obtained from patients with bronchiolitis obliterans syndrome ...

        Research

        Challenges posed by COVID-19 to children with cancer

        Development of standardised guidance by national and regional authorities for reducing the risk of SARS-CoV-2 transmission to children with cancer ...

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