In light of the obesity epidemic, we aimed to characterize novel childhood adiposity trajectories from birth to age 14 years and to determine their relation... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• April 2011

This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Glioblastoma is the most common form of high-grade glioma in adults and has a poor survival rate with very limited treatment options. There have been no significant advancements in glioblastoma treatment in over 30 years. Epidermal growth factor receptor is upregulated in most glioblastoma tumours and, therefore, has been a drug target in recent targeted therapy clinical trials. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

Topical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) or analogues of this compound are currently used with some succes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• July 2010

UVB-induced p53-mediated cell cycle arrest and apoptosis are reduced in the presence of heat stress, leading to increased survival of DNA damaged cells ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

The anti-inflammatory actions of IL-4 in activated human monocytes may reflect transcriptional regulation of genes involved in TLR signaling pathways. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• June 2012

The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

Shelley Prue Gorman Hart S PH BSc (Hons) PhD BSc (Hons) MSc PhD Honorary Research Associate Head, Inflammation shelley.gorman@telethonkids.org.au prue.hart@telethonkids.org.au Honorary Research Associate Head, Inflammation Shelley Gorman is a Group ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

The review provides the basis for further research into the effects of acute and chronic UV radiation exposure on skin cells in the context of vaccination ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Higher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

In malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence across different populations, settings, and timeframes is crucial to improving inference for supporting public health. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024